Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13874675 | 1.00 | DPP4 (0.38) | DPP4HRH3L3MBTL1SIGMAR1OPRL1 | |
| SCHEMBL13874570 | 0.88 | HRH3 (0.38) | HRH3L3MBTL1SIGMAR1OPRL1MEN1 | |
| SCHEMBL17753935 | 0.84 | L3MBTL1 (0.38) | HRH3L3MBTL1SIGMAR1OPRL1OPRM1 | |
| SCHEMBL23943527 | 0.81 | USP1 (0.32) | L3MBTL1 | |
| SCHEMBL3425370 | 0.79 | L3MBTL1 (0.40) | HRH3L3MBTL1 | |
| SCHEMBL11000044 | 0.78 | DPP4 (0.45) | DPP4HRH3OPRL1OPRM1 | |
| SCHEMBL1179599 | 0.77 | ALDH1A1 (0.35) | L3MBTL1SIGMAR1 | |
| SCHEMBL25743375 | 0.77 | DPP4 (0.33) | DPP4HRH3MEN1KMT2A | |
| SCHEMBL25743372 | 0.77 | DPP4 (0.33) | DPP4HRH3MEN1KMT2A | |
| SCHEMBL27291062 | 0.76 | DPP4 (0.47) | DPP4HRH3SIGMAR1OPRL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090093474-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | GRAUERT MATTHIAS | 2009-04-09 | — | — | US | disclosed |
| US-20070238718-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093474-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | CYP3A43, CYP3A5, UGT1A3 | DPP4 376/4885HRH3 387/4885L3MBTL1 3059/4885 |
| US-20070238718-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | CYP3A43, CYP3A5, UGT1A3 | DPP4 376/4885HRH3 387/4885L3MBTL1 3059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.