Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13181103 | 0.89 | MAPT (0.70) | MAPTALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL8932385 | 0.85 | MAPT (0.69) | MAPTALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL13153237 | 0.85 | MAPT (0.68) | MAPTALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL29057437 | 0.83 | MAPT (0.68) | MAPTALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL2074819 | 0.83 | MAPT (0.68) | MAPTALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL27783156 | 0.83 | AKR1C3 (0.85) | MAPTALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL6506583 | 0.82 | MAPT (0.66) | MAPTALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL7838695 | 0.82 | PKM (0.64) | ALDH1A1HTTSMN1; SMN2LMNAPOLB | |
| Ammonia Solution, Strong SCHEMBL27607455 | 0.82 | MAPT (0.66) | MAPTALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL31406888 | 0.82 | MAPT (0.64) | MAPTALDH1A1HTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H09505072-A | — | — | 1997-05-20 | — | — | JP | claimed |
| EP-0729455-A1 | INDOLE-DERIVED AZYLPIPERAZINES AS LIGANDS FOR 5HT1-LIKE RECEPTORS 5HT1B AND 5HT1D | PIERRE FABRE MEDICAMENT (FR) | 1996-09-04 | — | — | EP | claimed |
| WO-1995014004-A1 | INDOLE-DERIVED AZYLPIPERAZINES AS LIGANDS FOR 5HT1-LIKE RECEPTORS 5HT1B AND 5HT1D | PIERRE FABRE MEDICAMENT (FR) | 1995-05-26 | — | — | WO | claimed |
| US-20170014419-A1 | MEDICAMENT FOR SUPPRESSING MALIGNANT TUMOR METASTASIS | NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER (JP) | 2017-01-19 | — | — | US | disclosed |
| CN-101784520-B | Novel malonic acid sulfonamide derivative and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORP | 2014-07-02 | — | — | CN | disclosed |
| US-8461209-B2 | Malonic acid sulfonamide derivative and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-06-11 | — | — | US | disclosed |
| CN-101784520-A | Novel malonic acid sulfonamide derivative and pharmaceutical use thereof | MITSUBISHI TANABE PHARMA CORP | 2010-07-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170014419-A1 | MEDICAMENT FOR SUPPRESSING MALIGNANT TUMOR METASTASIS | AGTR2, MME, AGTR1 | MAPT 4456/4885ALDH1A1 2036/4885HTT 4790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.