Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 5/20 | 0.37 |
| ▸ | PDE4A | P27815 | 5/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13867003 | 0.87 | DPP4 (0.44) | HTR2C | |
| SCHEMBL13875686 | 0.85 | HTR2C (0.43) | HTR2CTLR7ENPP1PDE4APDE4B | |
| SCHEMBL13875889 | 0.83 | HTR2C (0.43) | HTR2CTLR7ENPP1ALDH1A1ADORA2B | |
| SCHEMBL13875776 | 0.82 | HTR2C (0.42) | HTR2CTLR7ENPP1PDE4APDE4B | |
| Trifluoroacetic Acid SCHEMBL3874829 | 0.80 | DPP4 (0.38) | HTR2C | |
| SCHEMBL13876133 | 0.75 | DPP4 (0.57) | KDM4EKMT2AMAPT | |
| SCHEMBL13875903 | 0.73 | HTR2C (0.50) | HTR2CTLR7ALDH1A1KDM4ENPC1 | |
| SCHEMBL13876313 | 0.73 | HTR2C (0.38) | HTR2CTLR7KDM4ENPC1MAPK1 | |
| SCHEMBL13866993 | 0.72 | DPP4 (0.44) | HTR2CTLR7PDE4APDE4BPDE4C | |
| SCHEMBL2914939 | 0.71 | PDGFRB (0.54) | HTR2CENPP1ALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524847-B2 | Fused 1,3-dihydro-imidazole ring compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-04-28 | — | — | US | disclosed |