Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | CKS1B | P61024 | 2/20 | 0.41 |
| ▸ | SKP1 | P63208 | 2/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3879673 | 0.89 | RET (0.40) | KCNH2RETCKS1BSKP1SKP2 | |
| SCHEMBL13876175 | 0.81 | ACHE (0.43) | KCNH2RETCKS1BSKP1SKP2 | |
| SCHEMBL13875886 | 0.73 | KCNH2 (0.44) | KCNH2RETGPR119KIT | |
| SCHEMBL2366669 | 0.72 | KIT (0.47) | KCNH2RETCKS1BSKP1SKP2 | |
| SCHEMBL31142858 | 0.72 | GBA1 (0.55) | CKS1BSKP1SKP2GPR119GBA1 | |
| SCHEMBL13876153 | 0.71 | KIT (0.54) | KCNH2CKS1BSKP1SKP2GPR119 | |
| SCHEMBL2919286 | 0.71 | PDGFRB (0.62) | KCNH2KIT | |
| SCHEMBL30867795 | 0.71 | RET (0.49) | KCNH2RETCKS1BSKP1SKP2 | |
| SCHEMBL20507720 | 0.71 | MAP4K4 (0.48) | KCNH2CKS1BSKP1SKP2GPR119 | |
| SCHEMBL899791 | 0.71 | NR1H2 (0.47) | KCNH2RETCKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7524847-B2 | Fused 1,3-dihydro-imidazole ring compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-04-28 | — | — | US | disclosed |