Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 3/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10365793 | 0.85 | DRD2 (0.61) | HTR1AALDH1A1KDM4ETDP1MEN1 | |
| SCHEMBL28729033 | 0.83 | KDM4E (0.65) | HTR1AALDH1A1KDM4ETDP1MEN1 | |
| SCHEMBL8444161 | 0.81 | DRD2 (0.62) | HTR1AALDH1A1KDM4ETDP1MEN1 | |
| SCHEMBL9652838 | 0.81 | DRD2 (0.69) | ADRA1AHTR1ADRD2 | |
| Ammonia Solution, Strong SCHEMBL8137510 | 0.80 | HTR1A (0.58) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| SCHEMBL5656389 | 0.79 | ADRA1D (0.65) | ADRA1DADRA1AADRA1BHTR1AHTR7 | |
| SCHEMBL8445581 | 0.79 | DRD2 (0.65) | HTR1AALDH1A1KDM4ETDP1DRD2 | |
| Benzene SCHEMBL10433203 | 0.79 | HTR1A (0.79) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| SCHEMBL3160665 | 0.79 | HTR1A (0.79) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 | |
| SCHEMBL15743486 | 0.79 | HTR1A (0.67) | ADRA1DADRA1AADRA1BHTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H09500883-A | — | — | 1997-01-28 | — | — | JP | claimed |
| EP-0711288-A1 | PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 1996-05-15 | — | — | EP | claimed |
| WO-1995004049-A1 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-02-09 | — | — | WO | claimed |
| EP-0711288-A1 | PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004049-A1 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-02-09 | — | — | WO | disclosed |