Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.65 |
| ▸ | HTR1A | P08908 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | DRD4 | P21917 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444161 | 0.86 | DRD2 (0.62) | DRD2HTR1AKDM4EALDH1A1DRD4 | |
| SCHEMBL8443516 | 0.85 | HTR1A (0.65) | DRD2HTR1AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL5656389 | 0.84 | ADRA1D (0.65) | DRD2HTR1ACYP1A2 | |
| SCHEMBL28729033 | 0.83 | KDM4E (0.65) | DRD2HTR1AKDM4EALDH1A1DRD4 | |
| SCHEMBL10365793 | 0.82 | DRD2 (0.61) | DRD2HTR1AKDM4EALDH1A1DRD4 | |
| SCHEMBL8443672 | 0.82 | ALDH1A1 (0.65) | DRD2HTR1AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL8445583 | 0.82 | DRD3 (0.61) | DRD2HTR1AKDM4EALDH1A1DRD4 | |
| SCHEMBL5656677 | 0.79 | ADRA1D (0.60) | DRD2HTR1AKDM4EALDH1A1TDP1 | |
| SCHEMBL1387947 | 0.79 | ADRA1D (0.64) | DRD2HTR1AKDM4EALDH1A1TDP1 | |
| SCHEMBL8446844 | 0.79 | DRD2 (0.66) | DRD2HTR1AKDM4EALDH1A1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0955296-A2 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-10 | — | — | EP | claimed |
| US-4988814-A | Antidepressants and/or anxiolytic agents | AMERICAN HOME PRODUCTS CORP. (US) | 1991-01-29 | — | — | US | claimed |
| EP-0395313-A2 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-31 | — | — | EP | claimed |