Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12345537 | 0.88 | NPC1 (0.62) | KMT2ANPC1RAB9APOLBBTK | |
| SCHEMBL13880860 | 0.82 | ALK (0.56) | LMNAALDH1A1SMN1; SMN2MAPTABCB1 | |
| SCHEMBL28668646 | 0.82 | PKM (0.79) | KMT2ANPC1RAB9ABTKPKM | |
| SCHEMBL15651745 | 0.82 | BTK (0.65) | KMT2ANPC1RAB9APOLBBTK | |
| SCHEMBL15381993 | 0.82 | ALDH1A1 (0.64) | KMT2ANPC1RAB9ABTKKIT | |
| SCHEMBL22017243 | 0.82 | KMT2A (0.57) | KMT2ANPC1RAB9APOLBBTK | |
| SCHEMBL21400972 | 0.80 | NPC1 (0.79) | KMT2ANPC1RAB9ABTKKIT | |
| SCHEMBL846560 | 0.79 | BTK (0.65) | NPC1RAB9ABTKKITALDH1A1 | |
| SCHEMBL31436860 | 0.79 | BTK (0.65) | NPC1RAB9ABTKKITALDH1A1 | |
| SCHEMBL12426361 | 0.79 | KMT2A (0.65) | KMT2APOLBSMN1; SMN2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2564850-A1 | Polo-like kinase inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2013-03-06 | — | — | EP | disclosed |
| WO-2009042711-A1 | POLO-LIKE KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |