Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 14/20 | 0.60 |
| ▸ | DRD3 | P35462 | 14/20 | 0.60 |
| ▸ | DRD2 | P14416 | 12/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | PRCP | P42785 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388785 | 0.82 | DRD4 (0.63) | DRD4DRD3DRD2CYP1A2CYP3A4 | |
| SCHEMBL1388702 | 0.77 | DRD4 (0.66) | DRD4DRD3DRD2CYP1A2CYP3A4 | |
| SCHEMBL9202400 | 0.77 | DRD4 (0.58) | DRD4DRD3DRD2CYP1A2CYP3A4 | |
| SCHEMBL1388392 | 0.73 | DRD4 (0.60) | DRD4DRD3DRD2CYP1A2CYP3A4 | |
| SCHEMBL1388774 | 0.73 | DRD4 (1.00) | DRD4DRD3DRD2CYP1A2CYP3A4 | |
| SCHEMBL7571134 | 0.72 | MEN1 (0.88) | DRD4DRD3DRD2ALDH1A1MEN1 | |
| SCHEMBL8274394 | 0.71 | LMNA (0.52) | DRD4DRD3DRD2TSHRMEN1 | |
| SCHEMBL1388694 | 0.71 | DRD2 (0.67) | DRD4DRD3DRD2CYP1A2CYP3A4 | |
| SCHEMBL1387864 | 0.71 | DRD4 (1.00) | DRD4DRD3DRD2CYP1A2CYP3A4 | |
| SCHEMBL6902946 | 0.70 | MEN1 (0.74) | DRD4DRD3DRD2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665833-B1 | DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME (GB) | 1999-07-14 | — | — | EP | claimed |
| JP-H08502508-A | — | — | 1996-03-19 | — | — | JP | claimed |
| WO-1994010145-A1 | DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1994-05-11 | — | — | WO | claimed |
| EP-0665833-B1 | DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME (GB) | 1999-07-14 | — | — | EP | disclosed |
| US-5668148-A | BENIGN PROSTATIC HYPERTROPHY | MERCK & CO., INC. (US) | 1997-09-16 | — | — | US | disclosed |
| US-5631269-A | Dopamine receptor subtype ligands | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-20 | — | — | US | disclosed |
| EP-0665833-A1 | DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1995-08-09 | — | — | EP | disclosed |
| WO-1994010145-A1 | DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1994-05-11 | — | — | WO | disclosed |