Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8273820 | 0.76 | ROCK2 (0.55) | PARP1ACHEDRD2DRD4DRD3 | |
| SCHEMBL8572563 | 0.75 | POLB (0.48) | ACHEDRD2DRD4DRD3MEN1 | |
| SCHEMBL30015144 | 0.74 | DRD2 (0.48) | ACHEDRD2DRD4DRD3HTR2A | |
| SCHEMBL2967028 | 0.74 | BCHE (0.47) | ACHEMAPK1DRD2DRD4DRD3 | |
| SCHEMBL1388463 | 0.71 | DRD4 (0.60) | ACHETSHRDRD2DRD4DRD3 | |
| SCHEMBL30944655 | 0.71 | ADRA1A (0.48) | ACHEMAPK1DRD4KMT2AGAA | |
| Maleic Acid SCHEMBL8569609 | 0.71 | HTR2A (0.46) | DRD2HTR2A | |
| SCHEMBL10164221 | 0.70 | ACHE (0.62) | ACHEDRD2HTR2A | |
| SCHEMBL5633507 | 0.69 | ACHE (0.54) | ACHEDRD2DRD4DRD3MEN1 | |
| SCHEMBL10499830 | 0.69 | CNR1 (0.46) | LMNASMN1; SMN2HPGDACHEMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006003147-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-01-12 | — | — | WO | disclosed |