Sugi Predict

Sugi Predict / Compounds / SCHEMBL138847

SCHEMBL138847

SCHEMBL138847

CC(=O)OC1CC(=O)C=C2CC[C@@H]3[C@H]([C@@H](O)C[C@@]4(C)[C@H]3CC[C@]4(O)C(=O)CO)[C@]21C

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HIF1A Q16665 13/20 0.66
▸ HSD17B10 Q99714 6/20 0.66
▸ CYP2C19 P33261 4/20 0.66
▸ PGR P06401 4/20 0.66
▸ SERPINA6 P08185 4/20 0.66
▸ CYP3A4 P08684 4/20 0.66
▸ SMN1; SMN2 Q16637 4/20 0.66
▸ NR3C1 P04150 3/20 0.66
▸ NR3C2 P08235 3/20 0.66
▸ KMT2A Q03164 2/20 0.66
▸ SHBG P04278 2/20 0.66
▸ NFKB1 P19838 2/20 0.66
▸ MAPT P10636 2/20 0.66
▸ AR P10275 2/20 0.60
▸ ABCB11 O95342 1/20 0.60
▸ TNF P01375 1/20 0.60
▸ IL6 P05231 1/20 0.60
▸ GLUL P15104 1/20 0.60
▸ ADAM17 P78536 1/20 0.60
▸ GPBAR1 Q8TDU6 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20553193 0.99 HIF1A (0.65) HIF1AHSD17B10CYP2C19PGRSERPINA6
SCHEMBL3999013 0.94 HIF1A (0.67) HIF1AHSD17B10CYP2C19PGRSERPINA6
SCHEMBL28553943 0.93 HIF1A (0.64) HIF1AHSD17B10CYP2C19PGRSERPINA6
SCHEMBL28809123 0.93 HIF1A (0.66) HIF1AHSD17B10CYP2C19PGRSERPINA6
SCHEMBL6001323 0.92 HIF1A (0.65) HIF1AHSD17B10CYP2C19PGRSERPINA6
SCHEMBL28715728 0.92 HIF1A (0.69) HIF1AHSD17B10CYP2C19PGRSERPINA6
SCHEMBL14931695 0.92 HIF1A (0.64) HIF1AHSD17B10CYP2C19PGRSERPINA6
SCHEMBL249836 0.92 HIF1A (0.64) HIF1AHSD17B10CYP2C19PGRSERPINA6
SCHEMBL29089932 0.92 HIF1A (0.64) HIF1AHSD17B10CYP2C19PGRSERPINA6
SCHEMBL28690820 0.92 HIF1A (0.64) HIF1AHSD17B10CYP2C19PGRSERPINA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1322 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024186108-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATION COMPRISING GLUCOCORTICOID COMPOUND 주식회사 에스씨엘테라퓨틱스 2024-09-12 — — WO claimed
CN-116507626-A Compositions and methods for modulating short-chain dehydrogenase activity 罗迪奥治疗公司 2023-07-28 — — CN claimed
US-20230192717-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY CASE WESTERN RESERVE UNIVERSITY 2023-06-22 — — US claimed
EP-4153299-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY Rodeo Therapeutics Corporation (US) 2023-03-29 — — EP claimed
US-20230039604-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY RODEO THERAPEUTICS CORPORATION 2023-02-09 — — US claimed
CN-112143771-B Method for producing prednisolone by microorganism one-step fermentation method 河南利华制药有限公司 2022-07-26 — — CN claimed
US-11352645-B2 Compositions and methods for treating Leber's hereditary optic neuropathy Wuhan Neurophth Biotechnology Limited Company (CN) 2022-06-07 — — US claimed
CN-108289833-B Stabilized assembled nanostructures for delivery of encapsulants 布里格姆及妇女医院股份有限公司 2022-01-25 — — CN claimed
WO-2021236779-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY RODEO THERAPEUTICS CORPORATION (US) 2021-11-25 — — WO claimed
CN-113507931-A Compositions and methods for modulating short-chain dehydrogenase activity 卡斯西部储备大学 2021-10-15 — — CN claimed
WO-2001041746-A1 ANTI ITCH PATCH LECTEC CORPORATION (US) 2001-06-14 — — WO claimed
EP-1067939-A1 USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS The Johns Hopkins University, School of Medicine, Office of Technology Licencing (US) 2001-01-17 — — EP claimed
WO-2000041545-A2 REGULATORS OF THE PCT OR SMOOTHENED PATHWAY, COMPOSITIONS AND USES RELATED THERETO ONTOGENY, INC. (US) 2000-07-20 — — WO claimed
WO-1999052534-A1 USE OF STEROIDAL ALKALOID DERIVATIVES AS INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) 1999-10-21 — — WO claimed
EP-0461108-B1 PARTIALLY FUSED PEPTIDE PELLET ENDOCON INC (US) 1994-06-01 — — EP claimed
US-5100662-A Steroidal liposomes exhibiting enhanced stability THE LIPOSOME COMPANY, INC. (US) 1992-03-31 — — US claimed
EP-0461108-A4 PARTIALLY FUSED PEPTIDE PELLET — 1992-03-18 — — EP claimed
EP-0461108-A1 PARTIALLY FUSED PEPTIDE PELLET. ENDOCON INC (US) 1991-12-18 — — EP claimed
US-5039660-A Partially fused peptide pellet ENDOCON, INC. (US) 1991-08-13 — — US claimed
WO-1990010437-A1 PARTIALLY FUSED PEPTIDE PELLET ENDOCON, INC. (US) 1990-09-20 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230039604-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY HPGD, GCDH, HPGDS HIF1A 874/4885HSD17B10 21/4885CYP2C19 519/4885
US-20230192717-A1 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY HPGD, GCDH, HPGDS HIF1A 874/4885HSD17B10 21/4885CYP2C19 519/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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