Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR5 | O14804 | 1/20 | 0.68 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.68 |
| ▸ | PCNA | P12004 | 11/20 | 0.67 |
| ▸ | LIG1 | P18858 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14308671 | 0.87 | TAAR5 (0.58) | TAAR5TAAR1PCNALIG1 | |
| SCHEMBL14485265 | 0.87 | PCNA (0.64) | TAAR5TAAR1PCNALIG1 | |
| SCHEMBL12921186 | 0.84 | THRB (0.68) | TAAR5TAAR1PCNAPOLBTHRA | |
| SCHEMBL22382794 | 0.84 | PCNA (0.67) | TAAR5TAAR1PCNALIG1POLB | |
| SCHEMBL14264010 | 0.84 | PCNA (0.67) | TAAR5TAAR1PCNALIG1POLB | |
| SCHEMBL16126016 | 0.84 | PCNA (0.65) | TAAR5TAAR1PCNALIG1 | |
| SCHEMBL13886596 | 0.82 | THRB (0.60) | TAAR5TAAR1PCNAPOLBTHRA | |
| SCHEMBL16124480 | 0.81 | PCNA (0.63) | TAAR5TAAR1PCNALIG1 | |
| SCHEMBL4005004 | 0.81 | PCNA (0.66) | TAAR5TAAR1PCNALIG1POLB | |
| SCHEMBL29374539 | 0.81 | TAAR1 (1.00) | TAAR5TAAR1MAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117554536-B | Simultaneous analysis method for 15 thyroid hormones in environmental water sample | 北京林业大学 | 2024-03-19 | — | — | CN | claimed |
| CN-117554536-A | Simultaneous analysis method for 15 thyroid hormones in environmental water sample | 北京林业大学 | 2024-02-13 | — | — | CN | claimed |
| CN-114609266-B | Application of marker in preparation of diagnostic reagent for thyroid related diseases | 徐州医科大学 | 2023-03-24 | — | — | CN | claimed |
| CN-114609265-B | Method for detecting eight thyroid hormone markers in serum by liquid chromatography tandem mass spectrometry technology | 徐州医科大学 | 2023-01-24 | — | — | CN | claimed |
| CN-114609266-A | Application of marker in preparation of diagnostic reagent for thyroid related diseases | 徐州医科大学 | 2022-06-10 | — | — | CN | claimed |
| CN-114609265-A | Method for detecting eight thyroid hormone markers in serum by liquid chromatography tandem mass spectrometry technology | 徐州医科大学 | 2022-06-10 | — | — | CN | claimed |
| CN-114609266-B | Application of marker in preparation of diagnostic reagent for thyroid related diseases | 徐州医科大学 | 2023-03-24 | — | — | CN | disclosed |
| CN-114609265-B | Method for detecting eight thyroid hormone markers in serum by liquid chromatography tandem mass spectrometry technology | 徐州医科大学 | 2023-01-24 | — | — | CN | disclosed |
| CN-112246221-B | Polyion liquid covalent organic framework material, preparation method and application thereof | 徐州医科大学 | 2023-01-20 | — | — | CN | disclosed |
| CN-112246221-B | Polyion liquid covalent organic framework material, preparation method and application thereof | 徐州医科大学 | 2023-01-20 | — | — | CN | disclosed |
| CN-114609265-A | Method for detecting eight thyroid hormone markers in serum by liquid chromatography tandem mass spectrometry technology | 徐州医科大学 | 2022-06-10 | — | — | CN | disclosed |
| CN-114609266-A | Application of marker in preparation of diagnostic reagent for thyroid related diseases | 徐州医科大学 | 2022-06-10 | — | — | CN | disclosed |
| US-20140288077-A1 | SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2014-09-25 | — | — | US | disclosed |
| US-20140288077-A1 | SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2014-09-25 | — | — | US | disclosed |
| WO-2013006734-A1 | SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2013-01-10 | — | — | WO | disclosed |
| US-20090105347-A1 | THYRONAMINE DERIVATIVES AND ANALOGS AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-04-23 | — | — | US | disclosed |
| US-7355079-B2 | Thyronamine derivatives and analogs and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-04-08 | — | — | US | disclosed |
| US-7355079-B2 | Thyronamine derivatives and analogs and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-04-08 | — | — | US | disclosed |
| US-7339079-B2 | Thyronamine derivatives and analogs and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-03-04 | — | — | US | disclosed |
| US-7321065-B2 | Thyronamine derivatives and analogs and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105347-A1 | THYRONAMINE DERIVATIVES AND ANALOGS AND METHODS OF USE THEREOF | TPO, TSHR, THRB | TAAR5 30/4885TAAR1 198/4885PCNA 4495/4885 |
| US-20140288077-A1 | SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY | MKI67, PCNA, PCLAF | TAAR5 4442/4885TAAR1 4477/4885PCNA 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.