Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.57 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 6/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL61188 | 0.85 | TNKS2 (0.50) | TNKS2ACVR1ADORA3DDAH1L3MBTL1 | |
| SCHEMBL405327 | 0.83 | KMT2A (0.61) | ACVR1ADORA3POLBGAAALDH1A1 | |
| SCHEMBL7722688 | 0.81 | TNKS2 (0.50) | TNKS2ADORA3DDAH1NPC1RAB9A | |
| SCHEMBL404756 | 0.78 | KDM4E (0.64) | TNKS2PARP1POLBGAAMAPT | |
| SCHEMBL401595 | 0.78 | MAPT (0.47) | ACVR1PARP1PARP2POLBNPC1 | |
| SCHEMBL403922 | 0.78 | POLB (0.49) | POLBMAPTSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL17298073 | 0.78 | PARP1 (0.65) | TNKS2ACVR1ADORA3DDAH1TP53 | |
| SCHEMBL28279923 | 0.78 | TNKS2 (0.58) | TNKS2ACVR1ADORA3DDAH1TP53 | |
| SCHEMBL405065 | 0.77 | PDE5A (0.64) | ACVR1POLBKMT2A | |
| SCHEMBL405713 | 0.77 | ALDH1A1 (0.48) | ACVR1POLBALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046205-A1 | PARP INHIBITOR COMPOUNDS, COMPOSITIONS AND METHODS OF USE | EISAI RESEARCH INSTITUTE (US) | 2009-04-09 | — | — | WO | disclosed |