Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | HTR1B | P28222 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2256189 | 0.91 | L3MBTL1 (0.41) | TLR8MCHR1GPBAR1CYSLTR1TSHR | |
| SCHEMBL1396371 | 0.90 | LTA4H (0.41) | TLR8MCHR1GPBAR1CYSLTR1MEN1 | |
| SCHEMBL2456698 | 0.88 | MCHR1 (0.41) | TLR8MCHR1GPBAR1CYSLTR1MEN1 | |
| SCHEMBL2458064 | 0.88 | MCHR1 (0.41) | TLR8MCHR1GPBAR1CYSLTR1MEN1 | |
| SCHEMBL6283599 | 0.88 | MCHR1 (0.41) | TLR8MCHR1GPBAR1CYSLTR1MEN1 | |
| SCHEMBL64412 | 0.85 | ALDH1A1 (0.34) | TLR8TDP1GAAL3MBTL1ALDH1A1 | |
| SCHEMBL2456166 | 0.85 | NCF1 (0.41) | MEN1KMT2ATSHRTDP1L3MBTL1 | |
| SCHEMBL1389303 | 0.85 | GPBAR1 (0.40) | TLR8MCHR1GPBAR1CYSLTR1KMT2A | |
| SCHEMBL2214684 | 0.84 | TSHR (0.39) | TSHRTDP1ALDH1A1CA2KDM4E | |
| SCHEMBL4629557 | 0.82 | AGXT (0.32) | TDP1CA12CA1CA9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3625223-B1 | PYRIMIDINE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2021-08-11 | — | — | EP | claimed |
| US-20200108068-A1 | PYRIMIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2020-04-09 | — | — | US | claimed |
| EP-3625223-A1 | PYRIMIDINE DERIVATIVES | Idorsia Pharmaceuticals Ltd (CH) | 2020-03-25 | — | — | EP | claimed |
| CN-110621667-A | Pyrimidine derivatives | 爱杜西亚药品有限公司 | 2019-12-27 | — | — | CN | claimed |
| WO-2018210992-A1 | PYRIMIDINE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-11-22 | — | — | WO | claimed |
| CN-105061505-A | Catalyst ligand, catalyst, and preparation methods and application thereof | USTC UNIV SCIENCE TECH CN | 2015-11-18 | — | — | CN | claimed |
| CN-118160125-A | Electrolyte, sodium ion secondary battery, battery module, battery pack, and electricity using device | 宁德时代新能源科技股份有限公司 | 2024-06-07 | — | — | CN | disclosed |
| EP-3625223-B1 | PYRIMIDINE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2021-08-11 | — | — | EP | disclosed |
| US-20200108068-A1 | PYRIMIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2020-04-09 | — | — | US | disclosed |
| EP-3625223-A1 | PYRIMIDINE DERIVATIVES | Idorsia Pharmaceuticals Ltd (CH) | 2020-03-25 | — | — | EP | disclosed |
| CN-110621667-A | Pyrimidine derivatives | 爱杜西亚药品有限公司 | 2019-12-27 | — | — | CN | disclosed |
| WO-2018210992-A1 | PYRIMIDINE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-11-22 | — | — | WO | disclosed |
| EP-2524686-B1 | PIGMENTATION-PREVENTING OR -AMELIORATING AGENT | POLA CHEM IND INC (JP) | 2017-06-21 | — | — | EP | disclosed |
| US-4197120-A | ELECTRICALLY PHOTOSENSITIVE PARTICLES CONTAINING COLORANT HAVING ABSORPTION MAXIMUM GREATER THAN 410 NANOMETERS | EASTMAN KODAK COMPANY (US) | 1980-04-08 | — | — | US | disclosed |
| US-4175961-A | DISPERSION OF A POLYMER HAVING ALKYLIDENE DIARYLENE GROUPS, A PYRYLIUM-TYPE DYE SALT, AND A BIS(N,N-DISUBSTITUTED ANILINE DERIVATIVE AS A SENSITIZER | EASTMAN KODAK COMPANY (US) | 1979-11-27 | — | — | US | disclosed |
| US-4127412-A | BIS(AMINOARYL)ALKANES | EASTMAN KODAK COMPANY (US) | 1978-11-28 | — | — | US | disclosed |
| US-4111693-A | PYRYLIUM TYPE DYE SALT | EASTMAN KODAK COMPANY (US) | 1978-09-05 | — | — | US | disclosed |
| US-4092162-A | Nitrogen containing polymers aelements | EASTMAN KODAK COMPANY (US) | 1978-05-30 | — | — | US | disclosed |
| US-4025341-A | CONDENSATION POLYMER OF A TERTIARY AROMATIC AMINE, A SENSITIZER, AND A CARBONYL COMPOUND | EASTMAN KODAK COMPANY (US) | 1977-05-24 | — | — | US | disclosed |
| US-4012376-A | Photosensitive colorant materials | EASTMAN KODAK COMPANY (US) | 1977-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200108068-A1 | PYRIMIDINE DERIVATIVES | PTGER1, PTGER4, PTGER2 | TLR8 1586/4885MCHR1 3550/4885GPBAR1 504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.