Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ACP3 | P15309 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10743675 | 0.98 | HTR2A (0.53) | HTR2ARETHTR2CSLC6A3EGFR | |
| SCHEMBL14407922 | 0.89 | HTR2A (0.55) | HTR2AHTR2CEGFRHRH1 | |
| SCHEMBL11229958 | 0.86 | MEN1 (0.44) | HTR2ARETACP3OPRM1 | |
| SCHEMBL9245535 | 0.86 | HTR2A (0.46) | HTR2ARETHTR2CSLC6A3EGFR | |
| SCHEMBL7597435 | 0.85 | HTR2A (0.45) | HTR2ARETHTR2CSLC6A3EGFR | |
| Hydrochloric Acid SCHEMBL9247364 | 0.85 | RET (0.45) | HTR2ARETHTR2CSLC6A3EGFR | |
| SCHEMBL10962986 | 0.85 | HTR2A (0.41) | HTR2ARETHTR2CSLC6A3EGFR | |
| SCHEMBL10743668 | 0.83 | HTR2A (0.53) | HTR2ARETHTR2CSLC6A3ACP3 | |
| SCHEMBL8615765 | 0.81 | AKR1B1 (0.45) | HTR2AHTR2CEGFRHRH1 | |
| SCHEMBL6301812 | 0.81 | TSHR (0.47) | HTR2ARETEGFRTSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | disclosed |
| US-8765730-B2 | 1-hydroxyimino-3-phenyl-propanes | Hoffmann-La Roche Inc (US) | 2014-07-01 | — | — | US | disclosed |
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-12 | — | — | US | disclosed |
| US-20080132562-A1 | TETRONIC AND TETRAMIC ACIDS | GODEL THIERRY | 2008-06-05 | — | — | US | disclosed |
| US-20050119329-A1 | Tetronic and tetramic acids | HOFFMANN-LA ROCHE INC. | 2005-06-02 | — | — | US | disclosed |
| EP-0772590-B1 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-10-09 | — | — | EP | disclosed |
| US-5449778-A | Peptide intermediates | WARNER-LAMBERT COMPANY (US) | 1995-09-12 | — | — | US | disclosed |
| EP-0637305-A1 | NOVEL CYCLIC AMINO ACIDS AND DERIVATIVES THEREOF | WARNER-LAMBERT COMPANY (US) | 1995-02-08 | — | — | EP | disclosed |
| US-5380925-A | Cyclic amino acids and derivatives thereof | WARNER-LAMBERT COMPANY (US) | 1995-01-10 | — | — | US | disclosed |
| US-5264577-A | Cyclic amino acids and derivatives thereof | WARNER-LAMBERT COMPANY (US) | 1993-11-23 | — | — | US | disclosed |
| WO-1993021176-A1 | NOVEL CYCLIC AMINO ACIDS AND DERIVATIVES THEREOF | WARNER-LAMBERT COMPANY (US) | 1993-10-28 | — | — | WO | disclosed |
| US-4691040-A | ANTIHISTAMINES, ANTIALLERGENS, HALIDES, SULFONATES, PYRROLIDINE | HOFFMANN-LA ROCHE INC. (US) | 1987-09-01 | — | — | US | disclosed |
| EP-0056617-B1 | CYCLOHEPTENE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, AND PHARMCEUTICALS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-11-13 | — | — | EP | disclosed |
| US-4513002-A | ATIALLERGENS;ANTIHISTAMINES | HOFFMANN-LA ROCHE INC. (US) | 1985-04-23 | — | — | US | disclosed |
| EP-0056617-A2 | Cycloheptene derivatives, process and intermediates for their preparation, and pharmceuticals containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-07-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132562-A1 | TETRONIC AND TETRAMIC ACIDS | BACE1, PSEN1, BACE2 | HTR2A 2974/4885RET 1266/4885HTR2C 4661/4885 |
| US-20050119329-A1 | Tetronic and tetramic acids | BACE1, PSEN1, BACE2 | HTR2A 2974/4885RET 1266/4885HTR2C 4661/4885 |
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | GPBAR1, GPR119, ADRB1 | HTR2A 204/4885RET 1629/4885HTR2C 216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.