Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.47 |
| ▸ | PPARA | Q07869 | 7/20 | 0.47 |
| ▸ | MAOA | P21397 | 4/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13899499 | 0.94 | MAOA (0.45) | PPARGPPARAMAOAMAOBKDM4E | |
| SCHEMBL13899336 | 0.88 | MAOA (0.54) | MAOAMAOBKDM4ENPC1RAB9A | |
| SCHEMBL13899500 | 0.87 | PPARG (0.48) | PPARGPPARAKDM4ELMNACYP3A4 | |
| SCHEMBL13899537 | 0.81 | LMNA (0.43) | PPARGPPARAKDM4ENPC1RAB9A | |
| SCHEMBL13899497 | 0.77 | PPARG (0.49) | PPARGPPARAMAOAMAOBKDM4E | |
| SCHEMBL13906089 | 0.76 | PPARG (0.43) | PPARGPPARAKDM4ELMNACYP3A4 | |
| SCHEMBL6310996 | 0.75 | PPARG (0.50) | PPARGPPARAKDM4ELMNAPKM | |
| SCHEMBL13899485 | 0.75 | KDM4E (0.47) | PPARGPPARAKDM4ENPC1RAB9A | |
| SCHEMBL923674 | 0.73 | MAOA (0.71) | MAOAMAOBKDM4ENPC1RAB9A | |
| SCHEMBL30791325 | 0.73 | MAOA (0.71) | MAOAMAOBKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507757-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507757-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-24 | — | — | US | disclosed |