Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.43 |
| ▸ | PPARA | Q07869 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13906048 | 0.89 | BCHE (0.46) | PPARGPPARALMNACYP3A4TSHR | |
| SCHEMBL13899510 | 0.86 | PPARG (0.46) | PPARGPPARALMNACYP3A4TSHR | |
| SCHEMBL13899497 | 0.82 | PPARG (0.49) | PPARGPPARALMNACYP3A4TSHR | |
| SCHEMBL13899499 | 0.81 | MAOA (0.45) | PPARGPPARACYP3A4KDM4EMAPK1 | |
| SCHEMBL13906024 | 0.77 | LMNA (0.41) | PPARGPPARALMNACYP3A4TSHR | |
| SCHEMBL13899355 | 0.76 | PPARG (0.47) | PPARGPPARALMNACYP3A4TSHR | |
| SCHEMBL13899537 | 0.76 | LMNA (0.43) | PPARGPPARALMNACYP3A4TSHR | |
| SCHEMBL13905955 | 0.75 | PPARA (0.41) | PPARGPPARA | |
| SCHEMBL13899481 | 0.74 | LMNA (0.46) | PPARGPPARALMNACYP3A4TSHR | |
| SCHEMBL13899509 | 0.74 | LMNA (0.46) | PPARGPPARALMNACYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507757-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-24 | — | — | US | disclosed |