Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 7/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13899500 | 0.88 | PPARG (0.48) | KDM4EALDH1A1SMN1; SMN2CYP3A4LMNA | |
| SCHEMBL13899336 | 0.86 | MAOA (0.54) | KDM4ECYP3A4MPORAB9ALMNA | |
| SCHEMBL13899537 | 0.86 | LMNA (0.43) | KDM4EALDH1A1SMN1; SMN2CYP3A4MPO | |
| SCHEMBL13906078 | 0.78 | LMNA (0.47) | KDM4EALDH1A1SMN1; SMN2CYP3A4MPO | |
| SCHEMBL13140182 | 0.76 | CMKLR1 (0.48) | KDM4EALDH1A1CYP3A4MPOLMNA | |
| SCHEMBL13899484 | 0.76 | LMNA (0.48) | KDM4EALDH1A1SMN1; SMN2CYP3A4MPO | |
| SCHEMBL3978471 | 0.76 | MAPT (0.42) | KDM4EALDH1A1CYP3A4MPOLMNA | |
| SCHEMBL13899355 | 0.75 | PPARG (0.47) | KDM4ECYP3A4MPORAB9ALMNA | |
| SCHEMBL4640180 | 0.74 | MPO (0.55) | KDM4EALDH1A1CYP3A4MPOMEN1 | |
| SCHEMBL24701303 | 0.74 | CYP3A4 (0.48) | KDM4EALDH1A1SMN1; SMN2CYP3A4MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507757-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507757-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-24 | — | — | US | disclosed |