Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13899497 | 0.91 | PPARG (0.49) | LMNAPKMCYP3A4TSHRMAPT | |
| SCHEMBL13899510 | 0.90 | PPARG (0.46) | LMNAPKMCYP3A4TSHRMAPT | |
| SCHEMBL13899484 | 0.89 | LMNA (0.48) | LMNAPKMCYP3A4TSHRBCHE | |
| SCHEMBL13906048 | 0.85 | BCHE (0.46) | LMNAPKMCYP3A4TSHRBCHE | |
| SCHEMBL13906078 | 0.81 | LMNA (0.47) | LMNAPKMCYP3A4TSHRSPHK2 | |
| SCHEMBL13899490 | 0.80 | LMNA (0.47) | LMNAPKMCYP3A4TSHRMAPT | |
| SCHEMBL13899509 | 0.78 | LMNA (0.46) | LMNAPKMCYP3A4TSHRMAPT | |
| SCHEMBL4640177 | 0.76 | LMNA (0.49) | LMNAPKMCYP3A4TSHRMAPT | |
| SCHEMBL13906089 | 0.74 | PPARG (0.43) | LMNAPKMCYP3A4TSHRBCHE | |
| SCHEMBL4640180 | 0.74 | MPO (0.55) | LMNAPKMCYP3A4TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507757-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-24 | — | — | US | disclosed |