Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.54 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.54 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 4/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.51 |
| ▸ | STK17A | Q9UEE5 | 11/20 | 0.48 |
| ▸ | STK17B | O94768 | 5/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13898099 | 0.89 | STK17A (0.55) | ULK1PDK1ULK2METALK | |
| SCHEMBL13901511 | 0.79 | TBK1 (0.46) | ULK1PDK1ULK2METALK | |
| SCHEMBL13901388 | 0.79 | ULK1 (0.43) | ULK1PDK1ULK2METALK | |
| SCHEMBL13901471 | 0.79 | MET (0.43) | ULK1PDK1ULK2METALK | |
| SCHEMBL13901366 | 0.79 | CCNT1 (0.44) | ULK1PDK1ULK2METALK | |
| SCHEMBL13901539 | 0.77 | JAK3 (0.43) | ULK1PDK1ULK2METALK | |
| SCHEMBL13901594 | 0.76 | BTK (0.45) | METALKSYK | |
| SCHEMBL13898230 | 0.76 | TBK1 (0.53) | ULK1PDK1ULK2STK17ASTK17B | |
| SCHEMBL13897359 | 0.76 | TBK1 (0.53) | ULK1PDK1ULK2STK17ASTK17B | |
| SCHEMBL13901592 | 0.76 | BRD4 (0.45) | ULK1PDK1ULK2METALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504410-B2 | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 2009-03-17 | — | — | US | disclosed |