Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.49 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8180741 | 0.94 | KMT2A (0.52) | ICMTL3MBTL1POLBPLA2G2AF2RL3 | |
| SCHEMBL8182875 | 0.91 | LMNA (0.50) | ICMTL3MBTL1POLBPLA2G2AF2RL3 | |
| SCHEMBL13931024 | 0.90 | LMNA (0.54) | ICMTL3MBTL1PLA2G2AF2RL3ALDH1A1 | |
| SCHEMBL8172638 | 0.90 | ICMT (0.48) | ICMTL3MBTL1POLBPLA2G2AALDH1A1 | |
| SCHEMBL8178890 | 0.90 | ICMT (0.47) | ICMTL3MBTL1POLBPLA2G2AALDH1A1 | |
| SCHEMBL8182894 | 0.90 | HTR6 (0.53) | ICMTL3MBTL1POLBPLA2G2AALDH1A1 | |
| SCHEMBL13931028 | 0.88 | PPARG (0.56) | ICMTL3MBTL1POLBPLA2G2AF2RL3 | |
| SCHEMBL8181059 | 0.87 | CHRNB2 (0.58) | L3MBTL1POLBPLA2G2AF2RL3ALDH1A1 | |
| SCHEMBL8186659 | 0.87 | ICMT (0.49) | ICMTL3MBTL1POLBPLA2G2AALDH1A1 | |
| SCHEMBL8172186 | 0.87 | POLB (0.53) | ICMTL3MBTL1POLBPLA2G2AF2RL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090047246-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090047246-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, HCCS | ICMT 2415/4885L3MBTL1 2670/4885POLB 330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.