Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | STAT6 | P42226 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14085821 | 0.69 | — | — | |
| SCHEMBL14987846 | 0.67 | — | — | |
| SCHEMBL12904624 | 0.67 | — | — | |
| SCHEMBL30198301 | 0.63 | PTGS2 (0.38) | PAX8PTGS2PKMCYP3A4ALDH1A1 | |
| SCHEMBL21563386 | 0.63 | PAX8 (0.50) | PAX8PTGS2PKMCYP3A4ALDH1A1 | |
| SCHEMBL13930920 | 0.61 | — | — | |
| SCHEMBL30463131 | 0.58 | PKM (0.47) | PAX8PTGS2PKMCYP3A4ALDH1A1 | |
| SCHEMBL14900980 | 0.58 | PKM (0.47) | PAX8PTGS2PKMCYP3A4ALDH1A1 | |
| SCHEMBL18334075 | 0.58 | PKM (0.47) | PAX8PTGS2PKMCYP3A4ALDH1A1 | |
| Coronopilin SCHEMBL8422737 | 0.58 | PAX8 (1.00) | PAX8PTGS2PKMCYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016565-A1 | TRICYCLIC COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2009-02-05 | — | — | WO | disclosed |