Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4164409 | 0.75 | ATM (0.50) | ATMMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL13806417 | 0.75 | ATM (0.50) | ATMMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL8512795 | 0.75 | ATM (0.50) | ATMMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL2796407 | 0.75 | ATM (0.50) | ATMMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL7479947 | 0.75 | ATM (0.50) | ATMMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL25413825 | 0.75 | ATM (0.50) | ATMMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL1285478 | 0.75 | ATM (0.50) | ATMMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL3732872 | 0.73 | ATM (0.39) | ATMKDM4E | |
| SCHEMBL2008748 | 0.73 | PARP1 (0.50) | ATMMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL19366748 | 0.71 | ATM (0.36) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206131-B2 | Compounds having antiparasitic or anti-infectious activity | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2015-12-08 | — | — | US | disclosed |
| US-20140045888-A1 | COMPOUNDS HAVING ANTIPARASITIC OR ANTI-INFECTIOUS ACTIVITY | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2014-02-13 | — | — | US | disclosed |
| US-8598354-B2 | Compounds having antiparasitic or anti-infectious activity | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-12-03 | — | — | US | disclosed |
| WO-2012167237-A2 | COMPOUNDS HAVING ANTIPARASITIC OR ANTI-INFECTIOUS ACTIVITY | MEDICINES FOR MALARIA VENTURE (CH) | 2012-12-06 | — | — | WO | disclosed |
| US-20120115904-A1 | COMPOUNDS HAVING ANTIPARASITIC OR ANTI-INFECTIOUS ACTIVITY | OREGON HEALTH & SCIENCE UNIVERSITY | 2012-05-10 | — | — | US | disclosed |
| US-20120010237-A1 | COMPOUNDS HAVING ANTIPARASITIC OR ANTI-INFECTIOUS ACTIVITY | THE GOVERNMENT OF THE UNITED STATES OF AMERICA DBA THE DEPARTMENT OF VETERANS AFFAIRS | 2012-01-12 | — | — | US | disclosed |
| US-6927293-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2005-08-09 | — | — | US | disclosed |
| US-20040192725-A1 | Tyrosine kinase inhibitors | MERCK & CO., INC. | 2004-09-30 | — | — | US | disclosed |
| WO-2003020276-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192725-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | ATM 242/4885MEN1 4406/4885KMT2A 3298/4885 |
| US-20120010237-A1 | COMPOUNDS HAVING ANTIPARASITIC OR ANTI-INFECTIOUS ACTIVITY | MASTL, RPS10, CBR3 | ATM 4243/4885MEN1 4637/4885KMT2A 3402/4885 |
| US-20140045888-A1 | COMPOUNDS HAVING ANTIPARASITIC OR ANTI-INFECTIOUS ACTIVITY | H1-10, RAB10, HDAC10 | ATM 4169/4885MEN1 3602/4885KMT2A 3053/4885 |
| US-20120115904-A1 | COMPOUNDS HAVING ANTIPARASITIC OR ANTI-INFECTIOUS ACTIVITY | H1-10, RAB10, HDAC10 | ATM 4131/4885MEN1 3614/4885KMT2A 2928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.