Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.67 |
| ▸ | HTR2C | P28335 | 8/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.53 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13942977 | 0.90 | PDE2A (0.69) | PDE2AHTR2CPDE5ATP53 | |
| SCHEMBL13942987 | 0.87 | PDE2A (0.66) | PDE2AHTR2CTP53ABL1SRC | |
| SCHEMBL13944357 | 0.86 | PIK3CA (0.61) | PDE2AHTR2CPIK3CAPDE5ATP53 | |
| SCHEMBL13943712 | 0.85 | PDE2A (0.63) | PDE2AHTR2CTP53BRD4 | |
| SCHEMBL13943288 | 0.82 | PDE2A (0.68) | PDE2AHTR2CPIK3CAPDE5APIK3CB | |
| SCHEMBL13944721 | 0.80 | HTR2C (0.74) | PDE2AHTR2CPIK3CAPDE5ATP53 | |
| SCHEMBL13943321 | 0.79 | TP53 (0.65) | PDE2AHTR2CPIK3CATP53BRD4 | |
| SCHEMBL13947356 | 0.79 | PIK3CA (0.57) | PDE2AHTR2CPIK3CAPDE5APIK3CB | |
| SCHEMBL13943315 | 0.78 | PIK3CA (0.63) | PDE2AHTR2CPIK3CAPDE5A | |
| SCHEMBL13947562 | 0.78 | PDE2A (0.77) | PDE2AHTR2CTP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |