Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.69 |
| ▸ | HTR2C | P28335 | 8/20 | 0.62 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13942987 | 0.91 | PDE2A (0.66) | PDE2AHTR2CTP53 | |
| SCHEMBL13943722 | 0.90 | PDE2A (0.67) | PDE2AHTR2CPDE5ATP53 | |
| SCHEMBL13943712 | 0.89 | PDE2A (0.63) | PDE2AHTR2CTP53 | |
| SCHEMBL13946800 | 0.86 | HTR2C (0.60) | PDE2AHTR2CHRH4PDE5AATAD2 | |
| SCHEMBL13946820 | 0.85 | HTR2C (0.70) | PDE2AHTR2CHRH4PDE5AHTR3A | |
| SCHEMBL13943321 | 0.81 | TP53 (0.65) | PDE2AHTR2CHRH4TP53HRH1 | |
| SCHEMBL13947132 | 0.80 | HTR2C (0.59) | PDE2AHTR2CHRH4PDE5AHTR3A | |
| SCHEMBL13943327 | 0.80 | TP53 (0.60) | PDE2AHTR2CHRH4PDE5AATAD2 | |
| SCHEMBL13943310 | 0.79 | HTR2C (0.65) | PDE2AHTR2CHRH4PDE5AHTR3A | |
| SCHEMBL13947562 | 0.79 | PDE2A (0.77) | PDE2AHTR2CTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |