Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.57 |
| ▸ | HTR2C | P28335 | 4/20 | 0.56 |
| ▸ | PDE5A | O76074 | 1/20 | 0.53 |
| ▸ | PDE2A | O00408 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | BCDIN3D | Q7Z5W3 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13947574 | 0.91 | PDE2A (0.55) | PIK3CAHTR2CPDE2ABCDIN3D | |
| SCHEMBL13943714 | 0.90 | HTR2C (0.58) | PIK3CAHTR2CPDE5APDE2ABCDIN3D | |
| SCHEMBL13943288 | 0.89 | PDE2A (0.68) | PIK3CAHTR2CPDE5APDE2APIK3CB | |
| SCHEMBL13942986 | 0.83 | CTNNB1 (0.48) | PIK3CAHTR2CPDE2ABCDIN3D | |
| SCHEMBL13944721 | 0.83 | HTR2C (0.74) | PIK3CAHTR2CPDE5APDE2AKDM4E | |
| SCHEMBL13943315 | 0.81 | PIK3CA (0.63) | PIK3CAHTR2CPDE5APDE2ABCDIN3D | |
| SCHEMBL13944174 | 0.80 | PDE2A (0.54) | PIK3CAHTR2CPDE5APDE2ABCDIN3D | |
| SCHEMBL2857759 | 0.80 | ALDH1A1 (0.44) | PIK3CAHTR2CPDE5APDE2AKDM4E | |
| SCHEMBL13943277 | 0.79 | PDE2A (0.70) | PIK3CAHTR2CPDE2ABCDIN3D | |
| SCHEMBL13943722 | 0.79 | PDE2A (0.67) | PIK3CAHTR2CPDE5APDE2APIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |