Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.63 |
| ▸ | HTR2C | P28335 | 7/20 | 0.60 |
| ▸ | HTR2A | P28223 | 5/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13942987 | 0.90 | PDE2A (0.66) | PDE2AHTR2CBRD4TP53 | |
| SCHEMBL13942977 | 0.89 | PDE2A (0.69) | PDE2AHTR2CTP53 | |
| SCHEMBL13943747 | 0.86 | HTR2A (0.70) | HTR2CHTR2ADRD3KDM4EALDH1A1 | |
| SCHEMBL13943722 | 0.85 | PDE2A (0.67) | PDE2AHTR2CBRD4TP53 | |
| SCHEMBL13943278 | 0.82 | HTR2C (0.63) | PDE2AHTR2CHTR2ADRD3KDM4E | |
| SCHEMBL13944359 | 0.81 | HTR2C (0.77) | PDE2AHTR2CHTR2ADRD3TP53 | |
| SCHEMBL13943327 | 0.80 | TP53 (0.60) | PDE2AHTR2CTP53 | |
| SCHEMBL13943310 | 0.79 | HTR2C (0.65) | PDE2AHTR2CHTR2ADRD3KDM4E | |
| SCHEMBL13946789 | 0.79 | TP53 (0.59) | PDE2AHTR2CBRD4TP53 | |
| SCHEMBL13946815 | 0.78 | HTR2C (0.72) | PDE2AHTR2CHTR2ADRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |