Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.60 |
| ▸ | HTR2C | P28335 | 8/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | PDE9A | O76083 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13944374 | 0.99 | PIK3CA (0.58) | PIK3CAHTR2CKDM4EMAPTPDE2A | |
| SCHEMBL13946800 | 0.92 | HTR2C (0.60) | PIK3CAHTR2CKDM4EPDE2ABCDIN3D | |
| SCHEMBL13944357 | 0.90 | PIK3CA (0.61) | PIK3CAHTR2CKDM4EPDE2AGAA | |
| SCHEMBL13943321 | 0.85 | TP53 (0.65) | PIK3CAHTR2CPDE2ABCDIN3DTP53 | |
| SCHEMBL27786579 | 0.82 | LMNA (0.60) | KDM4EMAPTALDH1A1GAAALOX15 | |
| SCHEMBL3644693 | 0.82 | HTR2C (0.58) | PIK3CAHTR2CPDE2AHTTBCDIN3D | |
| Hydrochloric Acid SCHEMBL3641122 | 0.81 | LMNA (0.61) | KDM4EMAPTALDH1A1GAAALOX15 | |
| SCHEMBL13947039 | 0.81 | BCDIN3D (0.62) | PIK3CAHTR2CPDE2ABCDIN3DLMNA | |
| SCHEMBL13947032 | 0.79 | BCDIN3D (0.61) | HTR2CKDM4EMAPTPDE2ABCDIN3D | |
| SCHEMBL13944731 | 0.79 | HTR2C (0.72) | PIK3CAHTR2CPDE2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |