Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 4/20 | 0.53 |
| ▸ | BCDIN3D | Q7Z5W3 | 8/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13943714 | 0.93 | HTR2C (0.58) | PDE2APIK3CAHTR2CBCDIN3DHRH1 | |
| SCHEMBL13947356 | 0.91 | PIK3CA (0.57) | PDE2APIK3CAHTR2CBCDIN3D | |
| SCHEMBL13942986 | 0.90 | CTNNB1 (0.48) | PDE2APIK3CAHTR2CBCDIN3D | |
| SCHEMBL13944174 | 0.89 | PDE2A (0.54) | PDE2APIK3CAHTR2CBCDIN3DHRH1 | |
| SCHEMBL2857759 | 0.88 | ALDH1A1 (0.44) | PDE2APIK3CAHTR2CCTSBCTSS | |
| SCHEMBL3644693 | 0.88 | HTR2C (0.58) | PDE2APIK3CAHTR2CBCDIN3DHRH1 | |
| SCHEMBL13943277 | 0.88 | PDE2A (0.70) | PDE2APIK3CAHTR2CBCDIN3DHRH4 | |
| SCHEMBL13947559 | 0.87 | NR3C1 (0.44) | PDE2APIK3CAHTR2CCTSBCTSS | |
| SCHEMBL13943266 | 0.86 | HTR2C (0.58) | PDE2APIK3CAHTR2CBCDIN3DHRH1 | |
| SCHEMBL13943321 | 0.81 | TP53 (0.65) | PDE2APIK3CAHTR2CBCDIN3DHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |