Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4203022 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2LIPGMEN1KMT2AL3MBTL1 | |
| SCHEMBL4203809 | 0.78 | MEN1 (0.61) | SMN1; SMN2LIPGMEN1KMT2AL3MBTL1 | |
| SCHEMBL1150428 | 0.72 | LIPG (0.58) | SMN1; SMN2LIPGMEN1KMT2AL3MBTL1 | |
| SCHEMBL823484 | 0.68 | LIPG (0.53) | SMN1; SMN2LIPGMEN1KMT2AL3MBTL1 | |
| SCHEMBL5644823 | 0.68 | LIPG (0.53) | SMN1; SMN2LIPGMEN1KMT2AL3MBTL1 | |
| SCHEMBL5519468 | 0.68 | LIPG (0.88) | SMN1; SMN2LIPGMEN1KMT2AL3MBTL1 | |
| SCHEMBL7048893 | 0.68 | KCNE1 (0.55) | SMN1; SMN2LIPGMEN1KMT2AL3MBTL1 | |
| SCHEMBL27635508 | 0.68 | KCNE1 (0.55) | SMN1; SMN2LIPGMEN1KMT2AL3MBTL1 | |
| SCHEMBL4390342 | 0.67 | KCNH2 (0.54) | SMN1; SMN2LIPGMEN1KMT2AL3MBTL1 | |
| SCHEMBL3525272 | 0.67 | LIPG (0.60) | SMN1; SMN2LIPGMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476666-B2 | HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-01-13 | — | — | US | disclosed |
| US-7476666-B2 | HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-01-13 | — | — | US | disclosed |
| US-20080015187-A1 | Hiv Integrase Inhibitors | MERCK SHARP & DOHME CORP. | 2008-01-17 | — | — | US | disclosed |
| US-20080015187-A1 | Hiv Integrase Inhibitors | MERCK SHARP & DOHME CORP. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015187-A1 | Hiv Integrase Inhibitors | REV1, ZC3HAV1, PNP | SMN1; SMN2 4093/4885LIPG 4242/4885MEN1 4287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.