Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 10/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | MMP13 | P45452 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CRHBP | P24387 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12700347 | 0.87 | HPGD (0.72) | HPGDMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL20830056 | 0.85 | HPGD (0.72) | HPGDMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL20828646 | 0.85 | HPGD (0.73) | HPGDMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL1394561 | 0.85 | HPGD (0.69) | HPGDMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL12062499 | 0.85 | HPGD (0.69) | HPGDMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL28707664 | 0.84 | HPGD (0.67) | HPGDMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL10107748 | 0.82 | HPGD (0.66) | HPGDMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL10107735 | 0.81 | HPGD (0.65) | HPGDMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL4925396 | 0.81 | MEN1 (0.84) | HPGDMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL10107742 | 0.81 | ALDH2 (0.77) | HPGDMEN1KMT2APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9370506-B2 | Modulators of aldehyde dehydrogenase and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-06-21 | — | — | US | disclosed |
| US-9370506-B2 | Modulators of aldehyde dehydrogenase and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-06-21 | — | — | US | disclosed |
| US-9370506-B2 | Modulators of aldehyde dehydrogenase and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-06-21 | — | — | US | disclosed |
| US-9315484-B2 | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | The Board of Trustees—Leland Stanford Junior University (US) | 2016-04-19 | — | — | US | disclosed |
| US-9315484-B2 | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | The Board of Trustees—Leland Stanford Junior University (US) | 2016-04-19 | — | — | US | disclosed |
| US-9315484-B2 | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | The Board of Trustees—Leland Stanford Junior University (US) | 2016-04-19 | — | — | US | disclosed |
| US-9273025-B2 | — | — | 2016-03-01 | — | — | US | disclosed |
| US-9273025-B2 | — | — | 2016-03-01 | — | — | US | disclosed |
| US-9273025-B2 | — | — | 2016-03-01 | — | — | US | disclosed |
| EP-2126574-B1 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF | UNIV LELAND STANFORD JUNIOR (US) | 2015-12-23 | — | — | EP | disclosed |
| US-20110105602-A2 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-05-05 | — | — | US | disclosed |
| US-20110105602-A2 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-05-05 | — | — | US | disclosed |
| US-20100113423-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2010-05-06 | — | — | US | disclosed |
| US-20100113423-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2010-05-06 | — | — | US | disclosed |
| US-20100113423-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2010-05-06 | — | — | US | disclosed |
| EP-2126574-A2 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF | The Board of Trustees of The Leland Stanford Junior University (US) | 2009-12-02 | — | — | EP | disclosed |
| US-20090082431-A1 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-03-26 | — | — | US | disclosed |
| US-20090082431-A1 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-03-26 | — | — | US | disclosed |
| US-20090082431-A1 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-03-26 | — | — | US | disclosed |
| WO-2008112164-A2 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2008-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105602-A2 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | ALDH2, ALDH5A1, AK2 | HPGD 184/4885MEN1 4768/4885KMT2A 2094/4885 |
| US-20090082431-A1 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF | ALDH2, ALDH5A1, AK2 | HPGD 184/4885MEN1 4768/4885KMT2A 2094/4885 |
| US-20100113423-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | ALDH2, ALDH3A1, ALDH1A1 | HPGD 86/4885MEN1 4664/4885KMT2A 2109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.