Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 6/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13933867 | 0.84 | ALDH1A1 (0.48) | SMN1; SMN2CYP2C19TSHRTDP1ALDH1A1 | |
| SCHEMBL13954050 | 0.83 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP1A2CYP2C19TSHRL3MBTL1 | |
| SCHEMBL14472724 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2CYP1A2CYP2C19TSHRL3MBTL1 | |
| SCHEMBL14349712 | 0.81 | KMT2A (0.60) | SMN1; SMN2KDM4ELMNAKMT2AMEN1 | |
| SCHEMBL13954051 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP1A2CYP2C19TSHRL3MBTL1 | |
| SCHEMBL6784915 | 0.75 | KMT2A (0.57) | TSHRL3MBTL1TDP1ALDH1A1KDM4E | |
| SCHEMBL7626936 | 0.74 | ALDH1A1 (0.63) | SMN1; SMN2CYP1A2CYP2C19TSHRL3MBTL1 | |
| SCHEMBL7635559 | 0.74 | ALDH1A1 (0.63) | SMN1; SMN2CYP1A2CYP2C19TSHRL3MBTL1 | |
| SCHEMBL7626813 | 0.74 | ALDH1A1 (0.63) | SMN1; SMN2CYP1A2CYP2C19TSHRL3MBTL1 | |
| SCHEMBL7630856 | 0.74 | ALDH1A1 (0.63) | SMN1; SMN2CYP1A2CYP2C19TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090042926-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042926-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | HCAR1, HCAR2, GPR119 | SMN1; SMN2 4003/4885CYP1A2 586/4885CYP2C19 618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.