Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14435242 | 0.92 | ADAM17 (0.42) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL14435240 | 0.92 | ADAM17 (0.42) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL12713172 | 0.86 | CALCA (0.47) | MC4RHPGDADAM17ADAMTS5 | |
| SCHEMBL12713306 | 0.85 | HDAC8 (0.48) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL14436415 | 0.84 | HDAC8 (0.46) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL14436419 | 0.84 | HDAC8 (0.46) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL13002996 | 0.84 | HDAC8 (0.46) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL14435273 | 0.83 | ADAM17 (0.39) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL13960290 | 0.82 | HDAC8 (0.41) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL12713297 | 0.80 | HDAC8 (0.51) | HDAC8HDAC1HDAC3HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096186-A1 | SUBSTITUTED PHENYLPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2007-08-30 | — | — | WO | disclosed |