Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.45 |
| ▸ | MMP1 | P03956 | 3/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP9 | P14780 | 3/20 | 0.42 |
| ▸ | MMP12 | P39900 | 3/20 | 0.42 |
| ▸ | MMP14 | P50281 | 3/20 | 0.42 |
| ▸ | MMP15 | P51511 | 3/20 | 0.42 |
| ▸ | MMP16 | P51512 | 3/20 | 0.42 |
| ▸ | MMP26 | Q9NRE1 | 3/20 | 0.42 |
| ▸ | MMP7 | P09237 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 5/20 | 0.40 |
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | CA9 | Q16790 | 5/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413279 | 1.00 | TAS2R14 (0.45) | TAS2R14MMP1MMP2MMP9MMP12 | |
| SCHEMBL4425654 | 0.83 | TAS2R14 (0.43) | TAS2R14MMP1MMP2MMP9MMP12 | |
| SCHEMBL4416979 | 0.83 | TAS2R14 (0.46) | TAS2R14MMP1MMP2MMP9MMP12 | |
| SCHEMBL4415220 | 0.81 | ALDH1A1 (0.44) | TAS2R14MMP2MMP9CA1CA2 | |
| SCHEMBL4418789 | 0.81 | VCAM1 (0.47) | TAS2R14CA1CA2CA9CA14 | |
| SCHEMBL4412965 | 0.80 | HCRTR1 (0.44) | TAS2R14MMP1MMP2MMP9MMP12 | |
| SCHEMBL13973059 | 0.79 | CA1 (0.49) | TAS2R14CA1CA2CA9CA14 | |
| SCHEMBL4422235 | 0.78 | KDM4E (0.48) | CA1CA2CA9CA14POLB | |
| SCHEMBL13972641 | 0.78 | GAA (0.40) | TAS2R14CA1CA2CA9CA14 | |
| SCHEMBL4416959 | 0.78 | GAA (0.40) | TAS2R14CA1CA2CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663983-B1 | N-SUBSTITUTED, 6,8-DIALKOXY-1,2,3,4-TETRAHYDRO-1H-ISOQUINOLINE AS POTASSIUM CHANNELS MODULATORS | 4SC AG (DE) | 2009-01-21 | — | — | EP | disclosed |