2'-Beta-Fluoro-2',3'-Deoxyadenosine

2'-Beta-Fluoro-2',3'-Deoxyadenosine

SCHEMBL13974294

Nc1ncnc2c1ncn2C1OC(CO)[C@@H](O)C1F

nearest known ligand 0.80

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 5/20 0.80
ADORA1 P30542 3/20 0.80
ADORA2A P29274 2/20 0.80
PI4KA P42356 2/20 0.80
PI4K2B Q8TCG2 2/20 0.80
PI4K2A Q9BTU6 2/20 0.80
PI4KB Q9UBF8 2/20 0.80
DPP4 P27487 1/20 0.80
MEN1 O00255 1/20 0.80
SLC28A1 O00337 1/20 0.80
MAP3K7 O43318 1/20 0.80
SLC28A2 O43868 1/20 0.80
GAPDH P04406 1/20 0.80
MAPK1 P28482 1/20 0.80
ADORA2B P29275 1/20 0.80
STAT6 P42226 1/20 0.80
KMT2A Q03164 1/20 0.80
SMN1; SMN2 Q16637 1/20 0.80
DOT1L Q8TEK3 1/20 0.80
SLC29A1 Q99808 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL12300496 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL20434791 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL66228 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL237404 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL383029 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL21081903 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL12031122 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL237405 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL1389499 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL13134603 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120296076-A1 PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS GILEAD SCIENCES, INC. 2012-11-22 US disclosed
WO-2012159047-A1 PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS GILEAD SCIENCES, INC. (US) 2012-11-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120296076-A1 PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS SAMHD1, DHPS, LSS ADORA3 2430/4885ADORA1 3543/4885ADORA2A 3746/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.