2'-Beta-Fluoro-2',3'-Deoxyadenosine

2'-Beta-Fluoro-2',3'-Deoxyadenosine

SCHEMBL383029

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)C1F

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 5/20 0.80
ADORA1 P30542 3/20 0.80
ADORA2A P29274 2/20 0.80
PI4KA P42356 2/20 0.80
PI4K2B Q8TCG2 2/20 0.80
PI4K2A Q9BTU6 2/20 0.80
PI4KB Q9UBF8 2/20 0.80
DPP4 P27487 1/20 0.80
MEN1 O00255 1/20 0.80
SLC28A1 O00337 1/20 0.80
MAP3K7 O43318 1/20 0.80
SLC28A2 O43868 1/20 0.80
GAPDH P04406 1/20 0.80
MAPK1 P28482 1/20 0.80
ADORA2B P29275 1/20 0.80
STAT6 P42226 1/20 0.80
KMT2A Q03164 1/20 0.80
SMN1; SMN2 Q16637 1/20 0.80
DOT1L Q8TEK3 1/20 0.80
SLC29A1 Q99808 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL12300496 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL20434791 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL66228 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL237404 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL21081903 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL12031122 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL237405 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL1389499 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL13974294 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B
2'-Beta-Fluoro-2',3'-Deoxyadenosine SCHEMBL13134603 1.00 ADORA3 (0.80) ADORA3ADORA1ADORA2API4KAPI4K2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 500 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250263678-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA REJUVENATION TECHNOLOGIES, INC. (US) 2025-08-21 US claimed
WO-2025081544-A1 PURINE NUCLEOSIDE PHOSPHORYLASE MUTANT AND PREPARATION METHOD FOR 2'-FLUORO NUCLEOSIDE 吉林凯莱英制药有限公司 2025-04-24 WO claimed
WO-2025081545-A1 PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE MUTANT AND PREPARATION METHOD FOR 2'-FLUORO NUCLEOSIDE 吉林凯莱英制药有限公司 2025-04-24 WO claimed
US-12083185-B2 Small polymeric carriers for delivery of agents University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2024-09-10 US claimed
EP-4379052-A2 MRNA PURIFICATION BY TANGENTIAL FLOW FILTRATION Ethris GmbH (DE) 2024-06-05 EP claimed
EP-4306643-A2 PLASMID CONTAINING A SEQUENCE ENCODING AN MRNA WITH A SEGMENTED POLY(A) TAIL ethris GmbH (DE) 2024-01-17 EP claimed
CN-116855471-B Purine nucleoside phosphorylase mutant and application thereof 江苏申基生物科技有限公司 2023-11-28 CN claimed
EP-4271389-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA Rejuvenation Technologies Inc. (US) 2023-11-08 EP claimed
CN-116855471-A Purine nucleoside phosphorylase mutant and application thereof 江苏申基生物科技有限公司 2023-10-10 CN claimed
WO-2022147039-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA REJUVENATION TECHNOLOGIES INC. (US) 2022-07-07 WO claimed
US-11021497-B2 Compositions and methods for synthesis of phosphorylated molecules THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-06-01 US claimed
US-20200239500-A1 Compositions and Methods for Synthesis of Phosphorylated Molecules THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2020-07-30 US claimed
WO-2019195494-A1 COMPOSITIONS AND METHODS FOR SYNTHESIS OF PHOSPHORYLATED MOLECULES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-10-10 WO claimed
EP-2360166-A1 Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase Merck Sharp & Dohme Corp. (US) 2011-08-24 EP claimed
US-7807653-B2 Nucleotide mimics and their prodrugs BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2010-10-05 US claimed
US-20070265224-A1 Nucleotide mimics and their prodrugs BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2007-11-15 US claimed
EP-1539188-A2 NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE Merck & Co., Inc. (US) 2005-06-15 EP claimed
US-20040110717-A1 Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase MERCK SHARP & DOHME LLC 2004-06-10 US claimed
US-20040059104-A1 Nucleotide mimics and their prodrugs BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2004-03-25 US claimed
WO-2002057425-A2 NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE MERCK & CO., INC. (US) 2002-07-25 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070265224-A1 Nucleotide mimics and their prodrugs NUDT14, ENTPD5, MTAP ADORA3 95/4885ADORA1 91/4885ADORA2A 103/4885
US-20200239500-A1 Compositions and Methods for Synthesis of Phosphorylated Molecules PIK3CA, CHAMP1, TYMP ADORA3 729/4885ADORA1 1078/4885ADORA2A 640/4885
US-20250263678-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF RNA RNASE1, POLRMT, TERT ADORA3 4335/4885ADORA1 4370/4885ADORA2A 3761/4885
US-20040110717-A1 Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase NSUN2, NSUN3, POLRMT ADORA3 304/4885ADORA1 493/4885ADORA2A 395/4885
US-12083185-B2 Small polymeric carriers for delivery of agents CD44, PGF, SLC46A1 ADORA3 4137/4885ADORA1 3740/4885ADORA2A 3965/4885
US-11021497-B2 Compositions and methods for synthesis of phosphorylated molecules PIK3CA, CHAMP1, TYMP ADORA3 729/4885ADORA1 1078/4885ADORA2A 640/4885
US-20040059104-A1 Nucleotide mimics and their prodrugs NUDT14, ENTPD5, MTAP ADORA3 95/4885ADORA1 91/4885ADORA2A 103/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.