Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | RORC | P51449 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18588560 | 0.93 | L3MBTL1 (0.53) | L3MBTL1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL13974868 | 0.86 | RORC (0.54) | RORCLMNAMAPTALDH1A1 | |
| SCHEMBL2471010 | 0.83 | ALDH1A1 (0.55) | RORCLMNAMAPTALDH1A1 | |
| SCHEMBL13974411 | 0.82 | RORC (0.65) | RORCLMNAPPARGMAPTSMN1; SMN2 | |
| SCHEMBL18588569 | 0.81 | HSD11B1 (0.56) | RORCLMNAALDH1A1 | |
| SCHEMBL2472684 | 0.81 | MAPT (0.59) | LMNAMAPTALDH1A1 | |
| SCHEMBL18595635 | 0.79 | RORC (0.60) | RORCPPARGMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13974921 | 0.77 | RORC (0.60) | L3MBTL1RORCPPARGALDH1A1 | |
| SCHEMBL15842097 | 0.76 | RORC (0.68) | RORCPPARGALDH1A1 | |
| SCHEMBL2472968 | 0.75 | ALDH1A1 (0.63) | L3MBTL1RORCLMNAPPARGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586928-B2 | Modulators of the nuclear hormone receptor ROR | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-03-07 | — | — | US | disclosed |
| WO-2012158784-A2 | MODULATORS OF THE NUCLEAR HORMONE RECEPTOR ROR | KAMENECKA THEODORE MARK (US) | 2012-11-22 | — | — | WO | disclosed |