Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.40 |
| ▸ | PPM1A | P35813 | 2/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13975119 | 0.95 | TRPA1 (0.40) | TRPA1PPM1AGPR3TRPV4PLA2G2A | |
| SCHEMBL13975867 | 0.95 | TRPV4 (0.43) | TRPA1PPM1AGPR3TRPV4PLA2G2A | |
| SCHEMBL13975118 | 0.89 | TRPV4 (0.43) | TRPA1PPM1AGPR3TRPV4PLA2G2A | |
| SCHEMBL13975120 | 0.89 | PPM1A (0.44) | PPM1AKDM4EALDH1A1NPSR1CYP1A2 | |
| SCHEMBL13975113 | 0.86 | KIF11 (0.46) | KDM4EALDH1A1HPGDPIM1CYP1A2 | |
| SCHEMBL13966278 | 0.86 | TRPV4 (0.39) | TRPA1PPM1AGPR3TRPV4CYP1A2 | |
| SCHEMBL13975971 | 0.82 | ACP1 (0.47) | KDM4EALDH1A1MAPTHPGDCYP1A2 | |
| SCHEMBL13975869 | 0.81 | TRPA1 (0.49) | TRPA1PPM1ATRPV4PLA2G2AKDM4E | |
| SCHEMBL13975868 | 0.81 | TRPA1 (0.46) | TRPA1TRPV4KDM4EALDH1A1MAPT | |
| SCHEMBL13976004 | 0.81 | TRPV4 (0.41) | TRPA1PPM1AGPR3TRPV4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8951964-B2 | Phenanthridine macrocyclic hepatitis C serine protease inhibitors | ABBVIE INC. (US) | 2015-02-10 | — | — | US | disclosed |
| US-20120295842-A1 | PHENANTHRIDINE MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ABBVIE INC. | 2012-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295842-A1 | PHENANTHRIDINE MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | TMPRSS15, HPN, PRSS1 | TRPA1 3785/4885PPM1A 3025/4885GPR3 2873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.