Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CENPE | Q02224 | 2/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1397708 | 0.93 | — | — | |
| SCHEMBL1397700 | 0.89 | MCL1 (0.31) | — | |
| SCHEMBL1397672 | 0.87 | EEF2K (0.30) | — | |
| SCHEMBL1397699 | 0.82 | C5AR1 (0.31) | — | |
| SCHEMBL1397377 | 0.81 | C5AR1 (0.31) | — | |
| SCHEMBL1397670 | 0.77 | ALDH1A1 (0.31) | MEN1ALDH1A1TP53CYP1A2CYP2C19 | |
| SCHEMBL1397763 | 0.76 | C5AR1 (0.32) | — | |
| SCHEMBL1385947 | 0.76 | ESRRG (0.36) | CENPESIGMAR1MEN1ALDH1A1TP53 | |
| SCHEMBL1397397 | 0.74 | C5AR1 (0.31) | — | |
| SCHEMBL1397368 | 0.74 | SIGMAR1 (0.31) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007726-B1 | BENZAMIDE AND HETEROARENE DERIVATIVES AS CETP INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-03-02 | — | — | EP | disclosed |