Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1397571 | 0.83 | SIGMAR1 (0.44) | SIGMAR1CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL3201138 | 0.73 | MEN1 (0.53) | MEN1MAPTKMT2AHPGD | |
| SCHEMBL23259441 | 0.72 | IGF1R (0.45) | IGF1RALOX15PNMTTAAR1SIGMAR1 | |
| SCHEMBL16978814 | 0.67 | GPR55 (0.41) | MEN1ALDH1A1MAPTKMT2AHPGD | |
| SCHEMBL9576639 | 0.64 | IGF1R (0.58) | IGF1RALOX15PNMTTAAR1SIGMAR1 | |
| SCHEMBL9177318 | 0.64 | SIGMAR1 (0.62) | IGF1RALOX15PNMTTAAR1SIGMAR1 | |
| SCHEMBL1448394 | 0.63 | SIGMAR1 (0.63) | IGF1RALOX15PNMTTAAR1SIGMAR1 | |
| SCHEMBL3566361 | 0.63 | SIGMAR1 (0.66) | IGF1RALOX15PNMTTAAR1SIGMAR1 | |
| SCHEMBL11443994 | 0.62 | IGF1R (0.60) | IGF1RALOX15PNMTTAAR1SIGMAR1 | |
| SCHEMBL12719081 | 0.62 | SKP2 (0.56) | IGF1RALOX15SIGMAR1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007726-B1 | BENZAMIDE AND HETEROARENE DERIVATIVES AS CETP INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-03-02 | — | — | EP | disclosed |