Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PNMT | P11086 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1397679 | 0.72 | IGF1R (0.42) | IGF1RALOX15PNMTTAAR1SIGMAR1 | |
| SCHEMBL9576639 | 0.70 | IGF1R (0.58) | IGF1RALOX15PNMTTAAR1SIGMAR1 | |
| SCHEMBL9177318 | 0.70 | SIGMAR1 (0.62) | IGF1RALOX15PNMTTAAR1SIGMAR1 | |
| SCHEMBL9073055 | 0.69 | CTRC (0.46) | ALOX15TAAR1SIGMAR1MEN1TP53 | |
| SCHEMBL1448394 | 0.69 | SIGMAR1 (0.63) | IGF1RALOX15PNMTTAAR1SIGMAR1 | |
| SCHEMBL3566361 | 0.69 | SIGMAR1 (0.66) | IGF1RALOX15PNMTTAAR1SIGMAR1 | |
| SCHEMBL11443994 | 0.68 | IGF1R (0.60) | IGF1RALOX15PNMTTAAR1SIGMAR1 | |
| SCHEMBL22333700 | 0.67 | SIGMAR1 (0.61) | IGF1RALOX15PNMTTAAR1SIGMAR1 | |
| SCHEMBL6481869 | 0.67 | PNMT (0.64) | IGF1RALOX15PNMTTAAR1SIGMAR1 | |
| SCHEMBL11066232 | 0.67 | SIGMAR1 (0.61) | IGF1RALOX15PNMTTAAR1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11225480-B2 | Malic enzyme inhibitors | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2022-01-18 | — | — | US | disclosed |
| US-20210115038-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2021-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210115038-A1 | MALIC ENZYME INHIBITORS | ME1, ME2, ME3 | IGF1R 1586/4885ALOX15 662/4885PNMT 1863/4885 |
| US-11225480-B2 | Malic enzyme inhibitors | ME1, RNASE1, ME2 | IGF1R 385/4885ALOX15 953/4885PNMT 3844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.