SCHEMBL13981274

SCHEMBL13981274

O=C1Nc2ccc(Cl)cc2C(c2ccccc2Cl)NC1O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.52
MAPT P10636 2/20 0.52
TP53 P04637 1/20 0.52
CYP1A2 P05177 1/20 0.52
CYP2C9 P11712 1/20 0.52
ALOX15 P16050 1/20 0.52
CASP1 P29466 1/20 0.52
CYP2C19 P33261 1/20 0.52
RECQL P46063 1/20 0.52
SLC8B1 Q6J4K2 1/20 0.52
LMNA P02545 2/20 0.45
PGR P06401 2/20 0.45
TRPM5 Q9NZQ8 1/20 0.44
CACNB4 O00305 1/20 0.43
CACNA1A O00555 1/20 0.43
CACNA1G O43497 1/20 0.43
CACNG3 O60359 1/20 0.43
CACNA1F O60840 1/20 0.43
CACNA1H O95180 1/20 0.43
CACNB3 P54284 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23721282 0.87 LMNA (0.42) TSHRMAPTTP53CYP1A2CYP2C9
SCHEMBL13981271 0.85 ATM (0.48) TSHRMAPTTP53CYP1A2CYP2C9
SCHEMBL28355878 0.78 MAPT (0.56) TSHRMAPTTP53CYP1A2CYP2C9
SCHEMBL5435436 0.77 MAPT (0.56) TSHRMAPTTP53CYP1A2CYP2C9
SCHEMBL5177430 0.72 MAPT (0.50) TSHRMAPTTP53CYP1A2CYP2C9
SCHEMBL11027115 0.71 CACNB4 (0.55) TSHRMAPTTP53CYP1A2CYP2C9
SCHEMBL11080410 0.70 MAPT (0.48) TSHRMAPTTP53CYP1A2CYP2C9
SCHEMBL8117192 0.69 MAPT (0.60) TSHRMAPTTP53CYP1A2CYP2C9
SCHEMBL1623970 0.69 ATM (0.46) TSHRMAPTTP53CYP1A2CYP2C9
SCHEMBL4110833 0.69 MAPT (0.55) TSHRMAPTTP53CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008145733-A2 NOVEL CHEMICAL COMPOUNDS, PRODUCTION THEREOF, AND USE THEREOF UNIVERSITÄT LEIPZIG (DE) 2008-12-04 WO disclosed