Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 1/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8370450 | 0.87 | LMNA (0.56) | CCR6TSHRMAPK1HIF1ACETP | |
| SCHEMBL2967940 | 0.85 | TRIM24 (0.55) | PDK2TRIM24TSHRMAPK1HIF1A | |
| SCHEMBL8370556 | 0.82 | MAPK1 (0.53) | TSHRMAPK1HIF1ACETP | |
| SCHEMBL13676825 | 0.82 | CCR6 (0.47) | CCR6PDK2TSHRMAOB | |
| SCHEMBL12251494 | 0.80 | TP53 (0.53) | PDK2TSHRMAPK1CHRM2CHRM1 | |
| SCHEMBL6049340 | 0.80 | CETP (0.43) | CCR6TSHRMAPK1HIF1ACETP | |
| SCHEMBL2608844 | 0.79 | KDM4E (0.54) | CCR6MAOB | |
| SCHEMBL3147185 | 0.79 | GPR3 (0.50) | CETPCHRM2CHRM1CHRM3 | |
| SCHEMBL11746054 | 0.79 | KIF11 (0.39) | CCR6TSHRMAPK1HIF1ACETP | |
| SCHEMBL5786398 | 0.78 | MAPK1 (0.64) | TRIM24TSHRMAPK1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468371-B2 | Tricyclic pyrazole kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-12-23 | — | — | US | disclosed |