Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10504393 | 0.84 | PTGS2 (0.54) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4173816 | 0.84 | MAPT (0.51) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4180130 | 0.83 | MAPT (0.51) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL6708261 | 0.83 | MEN1 (0.47) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL16388497 | 0.83 | ALDH1A1 (0.52) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL532856 | 0.82 | ALDH1A1 (0.56) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18586978 | 0.82 | TTR (0.52) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL531797 | 0.82 | POLB (0.58) | MEN1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL531660 | 0.81 | ALDH1A1 (0.54) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL12309435 | 0.80 | ALDH1A1 (0.68) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008150848-A1 | ANTIDEPRESSANT HETEROARYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2008-12-11 | — | — | WO | disclosed |