Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 7/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14320 | 0.93 | RIPK1 (0.42) | RIPK1SMYD3CCNCCDK8MAPK8 | |
| SCHEMBL13865 | 0.93 | RIPK1 (0.40) | RIPK1SMYD3MAPK8MAPKAPK2CHUK | |
| SCHEMBL14364 | 0.92 | RIPK1 (0.40) | RIPK1SMYD3TGFBR1BRD4KDM4E | |
| SCHEMBL12061506 | 0.91 | RIPK1 (0.39) | RIPK1ACVR1SMYD3BMPR1BBMPR1A | |
| SCHEMBL12061503 | 0.88 | MEN1 (0.38) | RIPK1CCNCCDK8MAPK8CHUK | |
| SCHEMBL12061496 | 0.88 | SMYD3 (0.38) | ACVR1SMYD3BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL14057 | 0.87 | RIPK1 (0.36) | RIPK1SMYD3MAPK8CHUKINSR | |
| SCHEMBL12061498 | 0.85 | CHRNA7 (0.38) | — | |
| SCHEMBL13764 | 0.85 | CHUK (0.37) | RIPK1MAPK8CHUKINSRCAMKK2 | |
| SCHEMBL12075844 | 0.85 | CHUK (0.45) | RIPK1MAPK8CHUKINSRCAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160031893-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | BioVersys AG (CH) | 2016-02-04 | — | — | US | disclosed |
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| WO-2011047319-A2 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031893-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MPO, LPO, CAT | RIPK1 2895/4885ACVR1 4858/4885SMYD3 1798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.