Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CCL2 | P13500 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13244758 | 0.90 | MMP13 (0.46) | HRH3 | |
| SCHEMBL13267473 | 0.79 | HRH3 (0.60) | HRH3SMN1; SMN2NPC1RAB9AATM | |
| SCHEMBL13244737 | 0.77 | HDAC6 (0.38) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL18023314 | 0.74 | HRH3 (0.64) | HRH3SMN1; SMN2NPC1RAB9AATM | |
| SCHEMBL24061141 | 0.69 | HRH3 (0.82) | HRH3SMN1; SMN2NPC1RAB9ANOS3 | |
| SCHEMBL13244713 | 0.69 | MMP2 (0.47) | HRH3 | |
| SCHEMBL24543121 | 0.69 | HRH3 (0.74) | HRH3SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL15467001 | 0.68 | HRH3 (0.87) | HRH3SMN1; SMN2NOS3NOS1NOS2 | |
| 4-(Biphenyl-4-Ylmethyl)Morpholine SCHEMBL1691308 | 0.68 | HRH3 (0.85) | HRH3SMN1; SMN2NPC1RAB9AATM | |
| SCHEMBL13266880 | 0.67 | HRH3 (0.61) | HRH3SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170814-B1 | ANTIBACTERIAL AGENTS | ACHAOGEN INC (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2008154642-A2 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2008-12-18 | — | — | WO | disclosed |