Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15382483 | 0.88 | MMP2 (0.49) | HRH3 | |
| SCHEMBL13267473 | 0.81 | HRH3 (0.60) | HRH3NPC1RAB9AATMHPGD | |
| SCHEMBL15467001 | 0.74 | HRH3 (0.87) | HRH3HPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL15382485 | 0.74 | LMNA (0.45) | HRH3RAB9AHPGDALDH1A1LMNA | |
| 4-(Biphenyl-4-Ylmethyl)Morpholine SCHEMBL1691308 | 0.74 | HRH3 (0.85) | HRH3NPC1RAB9AATMSMN1; SMN2 | |
| SCHEMBL29438462 | 0.74 | KMT2A (0.65) | HPGDALDH1A1LMNAHDAC1 | |
| SCHEMBL13266880 | 0.74 | HRH3 (0.61) | HRH3HPGDSMN1; SMN2AKR1C3 | |
| SCHEMBL13984676 | 0.74 | HRH3 (0.54) | HRH3NPC1RAB9AATMHPGD | |
| SCHEMBL254490 | 0.74 | HRH3 (0.72) | HRH3NPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL24061141 | 0.72 | HRH3 (0.82) | HRH3NPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170814-B1 | ANTIBACTERIAL AGENTS | ACHAOGEN INC (US) | 2016-08-17 | — | — | EP | disclosed |