Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.65 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828109 | 0.83 | SCN8A (0.58) | LOXL2SCN8ACHRM2CA12CA1 | |
| SCHEMBL17757708 | 0.82 | CHRM2 (0.67) | CHRM2MAOAHRH4HRH3LMNA | |
| SCHEMBL29912750 | 0.82 | LOXL2 (0.65) | LOXL2SCN8ACA12CA1CA2 | |
| SCHEMBL29038910 | 0.81 | SCN8A (0.54) | LOXL2SCN8ACHRM2CA12CA1 | |
| SCHEMBL6764034 | 0.81 | SCN8A (0.53) | LOXL2SCN8ACHRM2CA12CA1 | |
| SCHEMBL2201948 | 0.80 | SCN8A (0.50) | LOXL2SCN8ACHRM2CA12CA1 | |
| SCHEMBL509578 | 0.80 | LOXL2 (1.00) | LOXL2SCN8ACA12CA1CA2 | |
| SCHEMBL9885619 | 0.79 | SCN8A (0.55) | LOXL2SCN8ACHRM2CA12CA1 | |
| SCHEMBL9885618 | 0.79 | SCN8A (0.55) | LOXL2SCN8ACHRM2CA12CA1 | |
| Hydrochloric Acid SCHEMBL2205193 | 0.79 | SCN8A (0.49) | LOXL2SCN8ACHRM2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008153967-A1 | BK1 ANTAGONIST CONJUGATES | CONTEC THERAPEUTICS, INC. (US) | 2008-12-18 | — | — | WO | disclosed |