Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.78 |
| ▸ | PGR | P06401 | 9/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.78 |
| ▸ | LMNA | P02545 | 4/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.78 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.68 |
| ▸ | AR | P10275 | 3/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | APEX1 | P27695 | 1/20 | 0.68 |
| ▸ | IKBKB | O14920 | 1/20 | 0.68 |
| ▸ | CHUK | O15111 | 1/20 | 0.68 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.68 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22601611 | 1.00 | NR3C1 (0.78) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL12140907 | 1.00 | NR3C1 (0.78) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL13985476 | 0.90 | NR3C1 (0.75) | NR3C1PGRCYP3A4HIF1ALMNA | |
| Acrocinonide SCHEMBL1813445 | 0.90 | NR3C1 (0.74) | NR3C1PGRCYP3A4HIF1ALMNA | |
| Acrocinonide SCHEMBL11880454 | 0.90 | NR3C1 (0.74) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL27421144 | 0.89 | NR3C1 (0.73) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL10337827 | 0.89 | CYP3A4 (0.73) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL7134775 | 0.89 | CYP3A4 (0.73) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL7741442 | 0.89 | CYP3A4 (0.73) | NR3C1PGRCYP3A4HIF1ALMNA | |
| SCHEMBL6244781 | 0.88 | NR3C1 (0.72) | NR3C1PGRCYP3A4HIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170095565-A1 | CHEMICALLY MODIFIED SMALL MOLECULES | REDHILL BIOPHARMA LTD. (IL) | 2017-04-06 | — | — | US | disclosed |
| US-9388104-B2 | Chemically modified small molecules | NEKTAR THERAPEUTICS (US) | 2016-07-12 | — | — | US | disclosed |
| US-20150197470-A9 | CHEMICALLY MODIFIED SMALL MOLECULES | NEKTAR THERAPEUTICS (US) | 2015-07-16 | — | — | US | disclosed |
| US-20140303403-A1 | CHEMICALLY MODIFIED SMALL MOLECULES | NEKTAR THERAPEUTICS (US) | 2014-10-09 | — | — | US | disclosed |
| US-20120088745-A1 | CHEMICALLY MODIFIED SMALL MOLECULES | NEKTAR THERAPEUTICS | 2012-04-12 | — | — | US | disclosed |
| US-7645747-B2 | Improved pharmacokinetic properties, oral bioavailability; side effect reduction | GILEAD SCIENCES, INC. (US) | 2010-01-12 | — | — | US | disclosed |
| US-20090247488-A1 | ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS | CANNIZZARO CARINA | 2009-10-01 | — | — | US | disclosed |
| US-20090227543-A1 | PHOSPHONATE COMPOUNDS HAVING IMMUNO-MODULATORY ACTIVITY | CANNIZZARO CARINA | 2009-09-10 | — | — | US | disclosed |
| US-7470724-B2 | Phosphonate compounds having immuno-modulatory activity | GILEAD SCIENCES, INC. (US) | 2008-12-30 | — | — | US | disclosed |
| US-7432261-B2 | Anti-inflammatory phosphonate compounds | GILEAD SCIENCES, INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-3984544-A | Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor | SCHERING CORPORATION (US) | 1976-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227543-A1 | PHOSPHONATE COMPOUNDS HAVING IMMUNO-MODULATORY ACTIVITY | PHOSPHO1, NFATC1, IFNG | NR3C1 1066/4885PGR 3296/4885CYP3A4 3919/4885 |
| US-20170095565-A1 | CHEMICALLY MODIFIED SMALL MOLECULES | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CD44, PLG | NR3C1 2846/4885PGR 4398/4885CYP3A4 373/4885 |
| US-20090247488-A1 | ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS | PHOSPHO1, TNF, PTGES | NR3C1 310/4885PGR 1197/4885CYP3A4 1894/4885 |
| US-20120088745-A1 | CHEMICALLY MODIFIED SMALL MOLECULES | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CD44, PLG | NR3C1 2846/4885PGR 4398/4885CYP3A4 373/4885 |
| US-20150197470-A9 | CHEMICALLY MODIFIED SMALL MOLECULES | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CD44, PLG | NR3C1 2846/4885PGR 4398/4885CYP3A4 373/4885 |
| US-20140303403-A1 | CHEMICALLY MODIFIED SMALL MOLECULES | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CD44, PLG | NR3C1 2846/4885PGR 4398/4885CYP3A4 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.