Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986976 | 0.88 | P2RX7 (0.63) | GSK3BALDH1A1KMT2AP2RX7MEN1 | |
| SCHEMBL13986957 | 0.88 | GSK3B (0.56) | GSK3BKMT2AP2RX7POLBGAA | |
| SCHEMBL13986958 | 0.85 | LMNA (0.62) | GSK3BALDH1A1SMN1; SMN2KMT2AP2RX7 | |
| SCHEMBL13986986 | 0.83 | GSK3B (0.66) | GSK3BALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13986984 | 0.82 | GSK3B (0.63) | GSK3BALDH1A1SMN1; SMN2GAAPARP1 | |
| SCHEMBL13986993 | 0.82 | GSK3B (0.64) | GSK3BGAALMNAHDAC3HDAC4 | |
| SCHEMBL13986948 | 0.82 | GSK3B (0.54) | GSK3BALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13986973 | 0.82 | SIRT1 (0.56) | GSK3BSMN1; SMN2KMT2AMEN1NPC1 | |
| SCHEMBL4851138 | 0.81 | GSK3B (0.58) | GSK3BALDH1A1KMT2AP2RX7MEN1 | |
| SCHEMBL13986954 | 0.81 | GSK3B (0.55) | GSK3BALDH1A1SMN1; SMN2NPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |