SCHEMBL139923

SCHEMBL139923

C[SiH](C)[Zr](Cl)(Cl)(C1C(CC(C)(C)C)=Cc2c(-c3cccc4ccccc34)cccc21)C1C(CC(C)(C)C)=Cc2c(-c3cccc4ccccc34)cccc21

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CCR4 P51679 1/20 0.31
NPC1 O15118 1/20 0.30
MAPT P10636 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3072074 0.88
SCHEMBL716777 0.88 CCR4 (0.30) CCR4
SCHEMBL138908 0.87 ALOX15 (0.31)
SCHEMBL3066419 0.86
SCHEMBL138392 0.85 ALOX15 (0.32)
SCHEMBL146035 0.85
SCHEMBL1239458 0.84 CCR4 (0.31) CCR4
SCHEMBL5890108 0.84 ALOX15 (0.31)
SCHEMBL5951466 0.84 NPC1 (0.32) NPC1MAPTRAB9ASMN1; SMN2
SCHEMBL8461268 0.84 GSK3B (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8299287-B2 Metallocene compounds, catalysts comprising them, process for producing an olefin polymer by use of the catalysts, and olefin homo- and copolymers Lammus Novolen Technology GmbH (DE) 2012-10-30 US claimed
US-20100267907-A1 METALLOCENE COMPOUNDS, CATALYSTS COMPRISING THEM, PROCESS FOR PRODUCING AN OLEFIN POLYMER BY USE OF THE CATALYSTS, AND OLEFIN HOMO-AND COPOLYMERS LUMMUS NOVOLEN TECHNOLOGY GMBH (DE) 2010-10-21 US claimed
EP-2203483-A1 METALLOCENE COMPOUNDS, CATALYSTS COMPRISING THEM, PROCESS FOR PRODUCING AN OLEFIN POLYMER BY USE OF THE CATALYSTS, AND OLEFIN HOMO-AND COPOLYMERS Lummus Novolen Technology Gmbh (DE) 2010-07-07 EP claimed
WO-2009054832-A1 METALLOCENE COMPOUNDS, CATALYSTS COMPRISING THEM, PROCESS FOR PRODUCING AN OLEFIN POLYMER BY USE OF THE CATALYSTS, AND OLEFIN HOMO-AND COPOLYMERS NOVOLEN TECHNOLOGY HOLDINGS, C.V. (NL) 2009-04-30 WO claimed
EP-2415792-B1 COPOLYMER OF OLEFIN AND CONJUGATED DIENE, AND PROCESS FOR PRODUCING SAME MITSUI CHEMICALS INC (JP) 2014-11-12 EP disclosed
WO-2014070655-A1 SUPPORTED METALLOCENE CATALYST SYSTEMS AND METHODS OF PREPARATION THEREOF EXXONMOBIL CHEMICAL PATENTS INC. (US) 2014-05-08 WO disclosed
US-20140121341-A1 Supported Metallocene Catalyst Systems and Methods of Preparation Thereof EXXONMOBIL CHEMICAL PATENTS INC. 2014-05-01 US disclosed
US-8513368-B2 Copolymer of olefin and conjugated diene, and process for producing the same MITSUI CHEMICALS, INC. (JP) 2013-08-20 US disclosed
US-8507706-B2 Metallocene compounds, catalysts comprising them, process for producing an olefin polymer by use of the catalysts, and olefin homo- and copolymers LUMMUS NOVOLEN TECHNOLOGY GMBH (DE) 2013-08-13 US disclosed
US-20120329964-A1 METALLOCENE COMPOUNDS, CATALYSTS COMPRISING THEM, PROCESS FOR PRODUCING AN OLEFIN POLYMER BY USE OF THE CATALYSTS, AND OLEFIN HOMO- AND COPOLYMERS LUMMUS NOVOLEN TECHNOLOGY GMBH (DE) 2012-12-27 US disclosed
US-8299287-B2 Metallocene compounds, catalysts comprising them, process for producing an olefin polymer by use of the catalysts, and olefin homo- and copolymers Lammus Novolen Technology GmbH (DE) 2012-10-30 US disclosed
US-20120059135-A1 COPOLYMER OF OLEFIN AND CONJUGATED DIENE, AND PROCESS FOR PRODUCING THE SAME MITSUI CHEMICALS, INC. (JP) 2012-03-08 US disclosed
US-5936053-A RIGIDITY, HEAT RESISTANCE, IMPACT STRENGTH; LOW PROPORTION OF INVERSELY INSERTED PROPYLENE UNITS MITSUI CHEMICALS, INC. (JP) 1999-08-10 US disclosed
US-5723640-A Transition metal compound having indenyl-containing metallocene MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1998-03-03 US disclosed
US-5710223-A COORDINATION POLYMERIZATION CATALYSTS FOR PROPYLENE HOMOPOLYMERS AND COPOLYMERS MITSUI PETROCHEMICAL INDUSTRIES LTD. (JP) 1998-01-20 US disclosed
US-5705584-A COORDINATION CATALYSTS FOR ADDITION POLYMERIZATION OF PROPYLENE MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1998-01-06 US disclosed
EP-0812854-A2 Novel transition metal compound, olefin polymerization catalyst comprising said compound, process for olefin polymerization using said catalyst and propylene homo- and copolymer MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1997-12-17 EP disclosed
US-5658997-A USING ZIRCONIUM COMPOUND WITH ALUMINOXANE AND ORGANOALUMINUM COMPOUND MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1997-08-19 US disclosed
US-5629254-A Substituted indenyl ring containing metallocene catalyst for propylene polymerization process MITSUI PETROCHEMICAL INDUSTRIES CO., LTD. (JP) 1997-05-13 US disclosed
EP-0629632-A2 Novel transition metal compound for use as a polymerization catalyst MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1994-12-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120329964-A1 METALLOCENE COMPOUNDS, CATALYSTS COMPRISING THEM, PROCESS FOR PRODUCING AN OLEFIN POLYMER BY USE OF THE CATALYSTS, AND OLEFIN HOMO- AND COPOLYMERS PIN1, PCNA, OPRM1 CCR4 304/4885NPC1 4055/4885MAPT 1663/4885
US-20100267907-A1 METALLOCENE COMPOUNDS, CATALYSTS COMPRISING THEM, PROCESS FOR PRODUCING AN OLEFIN POLYMER BY USE OF THE CATALYSTS, AND OLEFIN HOMO-AND COPOLYMERS PIN1, PCNA, OPRM1 CCR4 304/4885NPC1 4055/4885MAPT 1663/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.